The 6-hydroxydopamine model: News from the past

Fabio Blandini, Marie Therese Armentero, Emilia Martignoni

Research output: Contribution to journalArticlepeer-review


The investigation of pathogenic and pathophysiological mechanisms of Parkinson's disease relies on experimental models reproducing, in the animal, the pathological and behavioural features of the disease. Despite the availability of innovative models, 6-hydroxydopamine (6-OHDA) remains the most widely used tool to induce a nigrostriatal lesion in the animal (rat). This is due to (1) the relatively low complexity and cost of the procedure, (2) the fact that the 6-OHDA-induced lesion is highly reproducible, and (3) the versatility of the procedure, which can yield varying degrees of nigrostriatal lesions that develop with different temporal profiles, depending on the site chosen for the toxin injection.

Original languageEnglish
JournalParkinsonism and Related Disorders
Issue numberSUPPL.2
Publication statusPublished - Jul 2008


  • Basal ganglia
  • Dopamine
  • Inflammation
  • Parkinson's disease
  • Striatum
  • Substantia nigra

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Neurology


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