TY - JOUR
T1 - The 6-hydroxydopamine model
T2 - News from the past
AU - Blandini, Fabio
AU - Armentero, Marie Therese
AU - Martignoni, Emilia
PY - 2008/7
Y1 - 2008/7
N2 - The investigation of pathogenic and pathophysiological mechanisms of Parkinson's disease relies on experimental models reproducing, in the animal, the pathological and behavioural features of the disease. Despite the availability of innovative models, 6-hydroxydopamine (6-OHDA) remains the most widely used tool to induce a nigrostriatal lesion in the animal (rat). This is due to (1) the relatively low complexity and cost of the procedure, (2) the fact that the 6-OHDA-induced lesion is highly reproducible, and (3) the versatility of the procedure, which can yield varying degrees of nigrostriatal lesions that develop with different temporal profiles, depending on the site chosen for the toxin injection.
AB - The investigation of pathogenic and pathophysiological mechanisms of Parkinson's disease relies on experimental models reproducing, in the animal, the pathological and behavioural features of the disease. Despite the availability of innovative models, 6-hydroxydopamine (6-OHDA) remains the most widely used tool to induce a nigrostriatal lesion in the animal (rat). This is due to (1) the relatively low complexity and cost of the procedure, (2) the fact that the 6-OHDA-induced lesion is highly reproducible, and (3) the versatility of the procedure, which can yield varying degrees of nigrostriatal lesions that develop with different temporal profiles, depending on the site chosen for the toxin injection.
KW - Basal ganglia
KW - Dopamine
KW - Inflammation
KW - Parkinson's disease
KW - Striatum
KW - Substantia nigra
UR - http://www.scopus.com/inward/record.url?scp=47049116273&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47049116273&partnerID=8YFLogxK
U2 - 10.1016/j.parkreldis.2008.04.015
DO - 10.1016/j.parkreldis.2008.04.015
M3 - Article
C2 - 18595767
AN - SCOPUS:47049116273
SN - 1353-8020
VL - 14
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
IS - SUPPL.2
ER -