The 5′ sequence of human Factor XII gene contains transcription regulatory elements typical of liver specific, estrogen-modulated genes

F. Citarella; S. Misiti; A. Felici; A. Aiuti; C. La Porta; A. Fantoni

doi:10.1016/0167-4781(93)90294-N

The 5′ sequence of human Factor XII gene contains transcription regulatory elements typical of liver specific, estrogen-modulated genes

F. Citarella, S. Misiti, A. Felici, A. Aiuti, C. La Porta, A. Fantoni

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The human Factor XII gene codes for a serine proteinase synthesized in liver that activates both the coagulation and the fibrinolytic cascades. The nucleotide sequence analysis of a HincII-HincII 3129 bp fragment was performed showing that the FXII promoter region contains neither CAAT and TATA regulatory elements, nor GC islands, but revealing the presence of two tandemly repeated sequences in opposite orientation, two LF-A1 elements typical of the liver specific genes and one estrogen responsive element, that substantiates the observation of Factor XII gene modulation by estrogens.

Original language	English
Pages (from-to)	197-199
Number of pages	3
Journal	BBA - Gene Structure and Expression
Volume	1172
Issue number	1-2
DOIs	https://doi.org/10.1016/0167-4781(93)90294-N
Publication status	Published - Feb 20 1993

Keywords

Estrogen
Factor XII
Fibrinolysis
Liver
Promoter

ASJC Scopus subject areas

Biochemistry
Biophysics
Genetics
Structural Biology

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10.1016/0167-4781(93)90294-N

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abstract = "The human Factor XII gene codes for a serine proteinase synthesized in liver that activates both the coagulation and the fibrinolytic cascades. The nucleotide sequence analysis of a HincII-HincII 3129 bp fragment was performed showing that the FXII promoter region contains neither CAAT and TATA regulatory elements, nor GC islands, but revealing the presence of two tandemly repeated sequences in opposite orientation, two LF-A1 elements typical of the liver specific genes and one estrogen responsive element, that substantiates the observation of Factor XII gene modulation by estrogens.",

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T1 - The 5′ sequence of human Factor XII gene contains transcription regulatory elements typical of liver specific, estrogen-modulated genes

AU - Citarella, F.

AU - Misiti, S.

AU - Felici, A.

AU - Aiuti, A.

AU - Porta, C. La

AU - Fantoni, A.

PY - 1993/2/20

Y1 - 1993/2/20

N2 - The human Factor XII gene codes for a serine proteinase synthesized in liver that activates both the coagulation and the fibrinolytic cascades. The nucleotide sequence analysis of a HincII-HincII 3129 bp fragment was performed showing that the FXII promoter region contains neither CAAT and TATA regulatory elements, nor GC islands, but revealing the presence of two tandemly repeated sequences in opposite orientation, two LF-A1 elements typical of the liver specific genes and one estrogen responsive element, that substantiates the observation of Factor XII gene modulation by estrogens.

AB - The human Factor XII gene codes for a serine proteinase synthesized in liver that activates both the coagulation and the fibrinolytic cascades. The nucleotide sequence analysis of a HincII-HincII 3129 bp fragment was performed showing that the FXII promoter region contains neither CAAT and TATA regulatory elements, nor GC islands, but revealing the presence of two tandemly repeated sequences in opposite orientation, two LF-A1 elements typical of the liver specific genes and one estrogen responsive element, that substantiates the observation of Factor XII gene modulation by estrogens.

KW - Estrogen

KW - Factor XII

KW - Fibrinolysis

KW - Liver

KW - Promoter

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The 5′ sequence of human Factor XII gene contains transcription regulatory elements typical of liver specific, estrogen-modulated genes

Abstract

Keywords

ASJC Scopus subject areas

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