The 2016 revision of the World Health Organization classification of lymphoid neoplasms

Steven H. Swerdlow; Elias Campo; Stefano A. Pileri; Nancy Lee Harris; Harald Stein; Reiner Siebert; Ranjana Advani; Michele Ghielmini; Gilles A. Salles; Andrew D. Zelenetz; Elaine S. Jaffe

doi:10.1182/blood-2016-01-643569

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

Steven H. Swerdlow, Elias Campo, Stefano A. Pileri, Nancy Lee Harris, Harald Stein, Reiner Siebert, Ranjana Advani, Michele Ghielmini, Gilles A. Salles, Andrew D. Zelenetz, Elaine S. Jaffe

Istituto Europeo di Oncologia

Research output: Contribution to journal › Review article › peer-review

Abstract

A revision of the nearly 8-year-old World Health Organization classification of the lymphoid neoplasms and the accompanying monograph is being published. It reflects a consensus among hematopathologists, geneticists, and clinicians regarding both updates to current entities as well as the addition of a limited number of new provisional entities. The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies. The major changes are reviewed with an emphasis on the most important advances in our understanding that impact our diagnostic approach, clinical expectations, and therapeutic strategies for the lymphoid neoplasms.

Original language	English
Pages (from-to)	2375-2390
Number of pages	16
Journal	Blood
Volume	127
Issue number	20
DOIs	https://doi.org/10.1182/blood-2016-01-643569
Publication status	Published - May 19 2016

ASJC Scopus subject areas

Hematology
Biochemistry
Cell Biology
Immunology

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title = "The 2016 revision of the World Health Organization classification of lymphoid neoplasms",

abstract = "A revision of the nearly 8-year-old World Health Organization classification of the lymphoid neoplasms and the accompanying monograph is being published. It reflects a consensus among hematopathologists, geneticists, and clinicians regarding both updates to current entities as well as the addition of a limited number of new provisional entities. The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies. The major changes are reviewed with an emphasis on the most important advances in our understanding that impact our diagnostic approach, clinical expectations, and therapeutic strategies for the lymphoid neoplasms.",

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AU - Swerdlow, Steven H.

AU - Campo, Elias

AU - Pileri, Stefano A.

AU - Lee Harris, Nancy

AU - Stein, Harald

AU - Siebert, Reiner

AU - Advani, Ranjana

AU - Ghielmini, Michele

AU - Salles, Gilles A.

AU - Zelenetz, Andrew D.

AU - Jaffe, Elaine S.

PY - 2016/5/19

Y1 - 2016/5/19

N2 - A revision of the nearly 8-year-old World Health Organization classification of the lymphoid neoplasms and the accompanying monograph is being published. It reflects a consensus among hematopathologists, geneticists, and clinicians regarding both updates to current entities as well as the addition of a limited number of new provisional entities. The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies. The major changes are reviewed with an emphasis on the most important advances in our understanding that impact our diagnostic approach, clinical expectations, and therapeutic strategies for the lymphoid neoplasms.

AB - A revision of the nearly 8-year-old World Health Organization classification of the lymphoid neoplasms and the accompanying monograph is being published. It reflects a consensus among hematopathologists, geneticists, and clinicians regarding both updates to current entities as well as the addition of a limited number of new provisional entities. The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies. The major changes are reviewed with an emphasis on the most important advances in our understanding that impact our diagnostic approach, clinical expectations, and therapeutic strategies for the lymphoid neoplasms.

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JO - Blood

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The 2016 revision of the World Health Organization classification of lymphoid neoplasms

Abstract

ASJC Scopus subject areas

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