Thalamocortical disconnection affects the somatic marker and social cognition: a case report

Laura Serra, Michela Bruschini, Cristina Ottaviani, Carlotta Di Domenico, Lucia Fadda, Carlo Caltagirone, Mara Cercignani, Giovanni Augusto Carlesimo, Marco Bozzali

Research output: Contribution to journalArticlepeer-review


Thalamo-cortical connectivity was characterised in a patient with bilateral infarct of the thalami, without evidence of cognitive deficits in everyday life. Patient underwent social and emotional tests, Iowa Gambling Task (IGT), with and without concomitant heart rate variability (HRV) recording and at 3T-MRI to assess thalamo-cortical connectivity. Patient showed impairment at the IGT, in somatic marker, in emotions and theory of mind. MRI documented a bilateral damage of the centromedian-parafascicular complex. Patient’s thalamic lesions disconnected brain areas involved in decision-making and autonomic regulation, affecting the somatic marker and resulting in the neuropsychological deficit exhibited by L.C.

Original languageEnglish
Publication statusPublished - Jan 1 2019


  • connectivity
  • MRI
  • social cognition
  • somatic marker
  • Thalamic lesions

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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