Thalamocortical disconnection affects the somatic marker and social cognition: a case report

Laura Serra; Michela Bruschini; Cristina Ottaviani; Carlotta Di Domenico; Lucia Fadda; Carlo Caltagirone; Mara Cercignani; Giovanni Augusto Carlesimo; Marco Bozzali

doi:10.1080/13554794.2019.1599025

Thalamocortical disconnection affects the somatic marker and social cognition: a case report

Laura Serra, Michela Bruschini, Cristina Ottaviani, Carlotta Di Domenico, Lucia Fadda, Carlo Caltagirone, Mara Cercignani, Giovanni Augusto Carlesimo, Marco Bozzali

Research output: Contribution to journal › Article › peer-review

Abstract

Thalamo-cortical connectivity was characterised in a patient with bilateral infarct of the thalami, without evidence of cognitive deficits in everyday life. Patient underwent social and emotional tests, Iowa Gambling Task (IGT), with and without concomitant heart rate variability (HRV) recording and at 3T-MRI to assess thalamo-cortical connectivity. Patient showed impairment at the IGT, in somatic marker, in emotions and theory of mind. MRI documented a bilateral damage of the centromedian-parafascicular complex. Patient’s thalamic lesions disconnected brain areas involved in decision-making and autonomic regulation, affecting the somatic marker and resulting in the neuropsychological deficit exhibited by L.C.

Original language	English
Journal	Neurocase
DOIs	https://doi.org/10.1080/13554794.2019.1599025
Publication status	Published - Jan 1 2019

Keywords

connectivity
MRI
social cognition
somatic marker
Thalamic lesions

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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10.1080/13554794.2019.1599025

Cite this

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title = "Thalamocortical disconnection affects the somatic marker and social cognition: a case report",

abstract = "Thalamo-cortical connectivity was characterised in a patient with bilateral infarct of the thalami, without evidence of cognitive deficits in everyday life. Patient underwent social and emotional tests, Iowa Gambling Task (IGT), with and without concomitant heart rate variability (HRV) recording and at 3T-MRI to assess thalamo-cortical connectivity. Patient showed impairment at the IGT, in somatic marker, in emotions and theory of mind. MRI documented a bilateral damage of the centromedian-parafascicular complex. Patient{\textquoteright}s thalamic lesions disconnected brain areas involved in decision-making and autonomic regulation, affecting the somatic marker and resulting in the neuropsychological deficit exhibited by L.C.",

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AU - Serra, Laura

AU - Bruschini, Michela

AU - Ottaviani, Cristina

AU - Di Domenico, Carlotta

AU - Fadda, Lucia

AU - Caltagirone, Carlo

AU - Cercignani, Mara

AU - Carlesimo, Giovanni Augusto

AU - Bozzali, Marco

PY - 2019/1/1

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AB - Thalamo-cortical connectivity was characterised in a patient with bilateral infarct of the thalami, without evidence of cognitive deficits in everyday life. Patient underwent social and emotional tests, Iowa Gambling Task (IGT), with and without concomitant heart rate variability (HRV) recording and at 3T-MRI to assess thalamo-cortical connectivity. Patient showed impairment at the IGT, in somatic marker, in emotions and theory of mind. MRI documented a bilateral damage of the centromedian-parafascicular complex. Patient’s thalamic lesions disconnected brain areas involved in decision-making and autonomic regulation, affecting the somatic marker and resulting in the neuropsychological deficit exhibited by L.C.

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KW - MRI

KW - social cognition

KW - somatic marker

KW - Thalamic lesions

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Thalamocortical disconnection affects the somatic marker and social cognition: a case report

Abstract

Keywords

ASJC Scopus subject areas

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