TY - JOUR
T1 - Th17 immune response in IBD
T2 - A new pathogenic mechanism
AU - Caprioli, Flavio
AU - Pallone, Francesco
AU - Monteleone, Giovanni
PY - 2008/12
Y1 - 2008/12
N2 - Although traditionally associated with exaggerated Th1 or Th2 cell response, the gut inflammation occurring in patients with IBD is also characterized by production of cytokines made by a distinct lineage of T helper cells, termed Th17 cells. The discovery that this new inflammatory T-cell subset drives immune-mediated pathology and that the antigen-presenting cell-derived IL-23 is necessary for amplifying Th17 cell-associated inflammation has contributed to elucidate new pathways of intestinal tissue damage as well as to open new avenues for development of therapeutic strategies in IBD. In this review, we discuss the available data regarding the involvement of Th17 cells and their interplay with other mucosal cell types in the modulation of intestinal tissue inflammation.
AB - Although traditionally associated with exaggerated Th1 or Th2 cell response, the gut inflammation occurring in patients with IBD is also characterized by production of cytokines made by a distinct lineage of T helper cells, termed Th17 cells. The discovery that this new inflammatory T-cell subset drives immune-mediated pathology and that the antigen-presenting cell-derived IL-23 is necessary for amplifying Th17 cell-associated inflammation has contributed to elucidate new pathways of intestinal tissue damage as well as to open new avenues for development of therapeutic strategies in IBD. In this review, we discuss the available data regarding the involvement of Th17 cells and their interplay with other mucosal cell types in the modulation of intestinal tissue inflammation.
KW - Crohn's disease
KW - IL-17
KW - IL-23
KW - Inflammatory bowel disease (IBD)
KW - Th17
KW - Ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=56449102268&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56449102268&partnerID=8YFLogxK
U2 - 10.1016/j.crohns.2008.05.004
DO - 10.1016/j.crohns.2008.05.004
M3 - Article
C2 - 21172226
AN - SCOPUS:56449102268
SN - 1873-9946
VL - 2
SP - 291
EP - 295
JO - Journal of Crohn's and Colitis
JF - Journal of Crohn's and Colitis
IS - 4
ER -