Tetanus toxoid IgE may be useful in predicting allergy during childhood

Giorgio Ciprandi, M. De Amici, S. Quaglini, E. Labò, A. M. Castellazzi, M. Miraglia Del Giudice, A. Marseglia, L. Bianchi, R. Moratti, G. L. Marseglia, M. Bosio, M. L. Fiorentini, R. Alesina, M. Luisetti, G. Borroni, M. Vignini, A. Spinillo, F. Perotti, M. Stronati, L. BollaniC. Cerra, B. Carugno

Research output: Contribution to journalArticlepeer-review


Hypersensitivity reactions after immunization with tetanus toxoid are occasionally observed in atopic and non-atopic individuals. High IgE levels in infancy may predict subsequent allergy. The aims of this study were: i) to evaluate the role of specific IgE to tetanus toxoid in children in response to tetanus immunization and the possible factors associated with specific IgE levels, and ii) to investigate the correlation between specific IgE levels to tetanus toxoid and the late development of allergy (up to 12 years). Initially, 278 healthy infants (152 males and 126 females, aged 12 months) living in an urban city were screened for serum total IgE and specific IgE to tetanus toxoid, after having obtained informed consent from parents. After 12 years, 151 children could be evaluated. Total IgE summed with tetanus specific IgE were significantly associated with allergy at 12 years. In conclusion, this study demonstrates that serum total IgE and tetanus specific IgE may be predictive of subsequent allergy onset.

Original languageEnglish
JournalJournal of Biological Regulators and Homeostatic Agents
Issue number1 SUPPL
Publication statusPublished - 2012


  • Allergy
  • IgE
  • Pediatrics
  • Tetanus toxoid

ASJC Scopus subject areas

  • Oncology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Immunology and Allergy
  • Immunology
  • Endocrinology
  • Physiology
  • Cancer Research


Dive into the research topics of 'Tetanus toxoid IgE may be useful in predicting allergy during childhood'. Together they form a unique fingerprint.

Cite this