Tenofovir-induced renal tubular dysfunction in vertically HIV-infected patients associated with polymorphisms in ABCC2, ABCC4 and ABCC10 genes

Vania Giacomet; Dario Cattaneo; Alessandra Viganò; Pilar Nannini; Valeria Manfredini; Giulia Ramponi; Emilio Clementi; Gian Vincenzo Zuccotti

doi:10.1097/INF.0b013e31829e6c9c

Tenofovir-induced renal tubular dysfunction in vertically HIV-infected patients associated with polymorphisms in ABCC2, ABCC4 and ABCC10 genes

Vania Giacomet, Dario Cattaneo, Alessandra Viganò, Pilar Nannini, Valeria Manfredini, Giulia Ramponi, Emilio Clementi, Gian Vincenzo Zuccotti

Istituto "Eugenio Medea" - Associazione La Nostra Famiglia

Research output: Contribution to journal › Article › peer-review

Abstract

Tenofovir disoproxyl fumarate is a known cause of kidney tubular dysfunction in HIV-infected patients. Recent studies reported significant association between specific allelic variants in ABCC2, ABCC4 and/ or ABCC10 genes and the development of kidney tubular dysfunction in HIV-infected adults. We describe the first 2 cases of vertically HIV-infected patients affected by kidney tubular dysfunction associated with polymorphisms in the ABCC genes.

Original language	English
Journal	Pediatric Infectious Disease Journal
Volume	32
Issue number	10
DOIs	https://doi.org/10.1097/INF.0b013e31829e6c9c
Publication status	Published - 2013

Keywords

HIV
Polymorphisms
Renal tubular dysfunction
Tenofovir

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Infectious Diseases
Microbiology (medical)

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10.1097/INF.0b013e31829e6c9c

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abstract = "Tenofovir disoproxyl fumarate is a known cause of kidney tubular dysfunction in HIV-infected patients. Recent studies reported significant association between specific allelic variants in ABCC2, ABCC4 and/ or ABCC10 genes and the development of kidney tubular dysfunction in HIV-infected adults. We describe the first 2 cases of vertically HIV-infected patients affected by kidney tubular dysfunction associated with polymorphisms in the ABCC genes.",

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AU - Giacomet, Vania

AU - Cattaneo, Dario

AU - Viganò, Alessandra

AU - Nannini, Pilar

AU - Manfredini, Valeria

AU - Ramponi, Giulia

AU - Clementi, Emilio

AU - Zuccotti, Gian Vincenzo

PY - 2013

Y1 - 2013

N2 - Tenofovir disoproxyl fumarate is a known cause of kidney tubular dysfunction in HIV-infected patients. Recent studies reported significant association between specific allelic variants in ABCC2, ABCC4 and/ or ABCC10 genes and the development of kidney tubular dysfunction in HIV-infected adults. We describe the first 2 cases of vertically HIV-infected patients affected by kidney tubular dysfunction associated with polymorphisms in the ABCC genes.

AB - Tenofovir disoproxyl fumarate is a known cause of kidney tubular dysfunction in HIV-infected patients. Recent studies reported significant association between specific allelic variants in ABCC2, ABCC4 and/ or ABCC10 genes and the development of kidney tubular dysfunction in HIV-infected adults. We describe the first 2 cases of vertically HIV-infected patients affected by kidney tubular dysfunction associated with polymorphisms in the ABCC genes.

KW - HIV

KW - Polymorphisms

KW - Renal tubular dysfunction

KW - Tenofovir

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Tenofovir-induced renal tubular dysfunction in vertically HIV-infected patients associated with polymorphisms in ABCC2, ABCC4 and ABCC10 genes

Abstract

Keywords

ASJC Scopus subject areas

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