TY - JOUR
T1 - Telomere length, c-myc and mad-1 expression could represent prognosis markers of myelodysplastic syndrome
AU - Poloni, Antonella
AU - Serrani, Federica
AU - Berardinelli, Eleonora
AU - Maurizi, Giulia
AU - Mariani, Marianna
AU - Costantini, Benedetta
AU - Trappolini, Silvia
AU - Mancini, Stefania
AU - Olivieri, Attilio
AU - Leoni, Pietro
PY - 2013/11
Y1 - 2013/11
N2 - Telomere dysfunction might generate genomic instability leading to the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). We investigated telomere length (TL), telomerase activity (TA) and hTERT, c-myc, mad1, and p53 expression in the bone marrow of patients with MDS (n= 109), AML (n= 47) and in controls (n= 24). TL was lower in MDS patients than in controls (p<0.001) and higher in L-MDS (low, intermediate-1 IPSS, p<0.01) respect H-MDS (high, intermediate-2 IPSS, p<0.01) patients. Mad-1 expression was higher in MDS patients than in controls (p<0.01), c-myc expression was highest in AML and in H-MDS patients. Our results show that the telomere dynamics might be useful for stratifying patients according to a risk scoring system.
AB - Telomere dysfunction might generate genomic instability leading to the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). We investigated telomere length (TL), telomerase activity (TA) and hTERT, c-myc, mad1, and p53 expression in the bone marrow of patients with MDS (n= 109), AML (n= 47) and in controls (n= 24). TL was lower in MDS patients than in controls (p<0.001) and higher in L-MDS (low, intermediate-1 IPSS, p<0.01) respect H-MDS (high, intermediate-2 IPSS, p<0.01) patients. Mad-1 expression was higher in MDS patients than in controls (p<0.01), c-myc expression was highest in AML and in H-MDS patients. Our results show that the telomere dynamics might be useful for stratifying patients according to a risk scoring system.
KW - Acute myeloid leukemia
KW - HTERT
KW - Myelodysplastic syndromes
KW - Telomerase activity
KW - Telomere length
KW - Transcription factors
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U2 - 10.1016/j.leukres.2013.07.022
DO - 10.1016/j.leukres.2013.07.022
M3 - Article
C2 - 24095110
AN - SCOPUS:84886778483
SN - 0145-2126
VL - 37
SP - 1538
EP - 1544
JO - Leukemia Research
JF - Leukemia Research
IS - 11
ER -