Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer

R. Bertorelle; M. Briarava; E. Rampazzo; L. Biasini; M. Agostini; I. Maretto; S. Lonardi; M. L. Friso; C. Mescoli; V. Zagonel; D. Nitti; A. De Rossi; S. Pucciarelli

doi:10.1038/bjc.2012.602

Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer

R. Bertorelle, M. Briarava, E. Rampazzo, L. Biasini, M. Agostini, I. Maretto, S. Lonardi, M. L. Friso, C. Mescoli, V. Zagonel, D. Nitti, A. De Rossi, S. Pucciarelli

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

Background:Colorectal cancer (CRC) is an important cause of cancer-related death. Prediction of recurrence is an important issue in the treatment of disease, particularly for stage II patients. The level of telomere-specific reverse transcriptase (hTERT), the catalytic component of the telomerase complex, increases along with CRC progression, but its prognostic value is still unclear.Methods:One hundred and thirty-seven CRC patients were studied for hTERT expression in tumour cells by real-time PCR. hTERT level was evaluated as a prognostic factor of overall survival (OS) in all patients and of disease recurrence in a subgroup of 50 stage II patients.Results:The median hTERT level was 93.8 copies (interquartile range 48-254). Patients with high hTERT levels (above the median) showed a significantly worse survival than those with low hTERT levels (below the median; log-rank test P

Original language	English
Pages (from-to)	278-284
Number of pages	7
Journal	British Journal of Cancer
Volume	108
Issue number	2
DOIs	https://doi.org/10.1038/bjc.2012.602
Publication status	Published - Feb 2013

Keywords

Colorectal cancer
hTERT
Prognostic marker

ASJC Scopus subject areas

Cancer Research
Oncology

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10.1038/bjc.2012.602

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Bertorelle, R., Briarava, M., Rampazzo, E., Biasini, L., Agostini, M., Maretto, I., Lonardi, S., Friso, M. L., Mescoli, C., Zagonel, V., Nitti, D., De Rossi, A., & Pucciarelli, S. (2013). Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer. British Journal of Cancer, 108(2), 278-284. https://doi.org/10.1038/bjc.2012.602

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abstract = "Background:Colorectal cancer (CRC) is an important cause of cancer-related death. Prediction of recurrence is an important issue in the treatment of disease, particularly for stage II patients. The level of telomere-specific reverse transcriptase (hTERT), the catalytic component of the telomerase complex, increases along with CRC progression, but its prognostic value is still unclear.Methods:One hundred and thirty-seven CRC patients were studied for hTERT expression in tumour cells by real-time PCR. hTERT level was evaluated as a prognostic factor of overall survival (OS) in all patients and of disease recurrence in a subgroup of 50 stage II patients.Results:The median hTERT level was 93.8 copies (interquartile range 48-254). Patients with high hTERT levels (above the median) showed a significantly worse survival than those with low hTERT levels (below the median; log-rank test P",

keywords = "Colorectal cancer, hTERT, Prognostic marker",

author = "R. Bertorelle and M. Briarava and E. Rampazzo and L. Biasini and M. Agostini and I. Maretto and S. Lonardi and Friso, {M. L.} and C. Mescoli and V. Zagonel and D. Nitti and {De Rossi}, A. and S. Pucciarelli",

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doi = "10.1038/bjc.2012.602",

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AU - Bertorelle, R.

AU - Briarava, M.

AU - Rampazzo, E.

AU - Biasini, L.

AU - Agostini, M.

AU - Maretto, I.

AU - Lonardi, S.

AU - Friso, M. L.

AU - Mescoli, C.

AU - Zagonel, V.

AU - Nitti, D.

AU - De Rossi, A.

AU - Pucciarelli, S.

PY - 2013/2

Y1 - 2013/2

N2 - Background:Colorectal cancer (CRC) is an important cause of cancer-related death. Prediction of recurrence is an important issue in the treatment of disease, particularly for stage II patients. The level of telomere-specific reverse transcriptase (hTERT), the catalytic component of the telomerase complex, increases along with CRC progression, but its prognostic value is still unclear.Methods:One hundred and thirty-seven CRC patients were studied for hTERT expression in tumour cells by real-time PCR. hTERT level was evaluated as a prognostic factor of overall survival (OS) in all patients and of disease recurrence in a subgroup of 50 stage II patients.Results:The median hTERT level was 93.8 copies (interquartile range 48-254). Patients with high hTERT levels (above the median) showed a significantly worse survival than those with low hTERT levels (below the median; log-rank test P

AB - Background:Colorectal cancer (CRC) is an important cause of cancer-related death. Prediction of recurrence is an important issue in the treatment of disease, particularly for stage II patients. The level of telomere-specific reverse transcriptase (hTERT), the catalytic component of the telomerase complex, increases along with CRC progression, but its prognostic value is still unclear.Methods:One hundred and thirty-seven CRC patients were studied for hTERT expression in tumour cells by real-time PCR. hTERT level was evaluated as a prognostic factor of overall survival (OS) in all patients and of disease recurrence in a subgroup of 50 stage II patients.Results:The median hTERT level was 93.8 copies (interquartile range 48-254). Patients with high hTERT levels (above the median) showed a significantly worse survival than those with low hTERT levels (below the median; log-rank test P

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KW - Prognostic marker

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Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer

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