T cell defect in essential mixed cryoglobulinaemia

P. L. Meroni, G. F. Ciboddo, G. Colombo, P. Bonara, F. Invernizzi

Research output: Contribution to journalArticlepeer-review


Peripheral blood lymphocytes from untreated patients with essential cryoglobulinaemia were studied for their surface markers and for their in vitro mitogenic reactivity. No differences in lymphocyte subpopulations were observed between cryoglobulinaemic patients and normal controls. Cultures of separated lymphocytes were stimulated with different concentrations of phytohaemagglutinin, Con-A and pokeweed mitogen. Incorporation of [ 3H]-thymidine in patients' cultures was compared with that of normal controls. Significantly decreased reactivity to phytohaemagglutinin and Con-A, but not to pokeweed mitogen, was found in all patients studied. The depresssed mitogenic reactivity to phytohaemagglutinin and Con-A might be referred to a qualitative T cell defect.

Original languageEnglish
Pages (from-to)308-314
Number of pages7
JournalInternational Archives of Allergy and Applied Immunology
Issue number3
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Immunology and Allergy


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