TY - JOUR
T1 - Systemic vascular inflammation in abdominal aortic aneurysm patients
T2 - A contrast-enhanced PET/CT study
AU - Morbelli, S.
AU - Ghigliotti, G.
AU - Spinella, G.
AU - Marini, C.
AU - Bossert, I.
AU - Cimmino, M. A.
AU - Pane, B.
AU - Rousas, N.
AU - Cittadini, G.
AU - Massollo, M.
AU - Camellino, D.
AU - Riondato, M.
AU - Palombo, D.
AU - Barisione, C.
AU - Sambuceti, G.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Aim. The aim of this paper was to investigate the presence of systemic vascular inflammation and its relationship with risk factors and biomarkers of systemic inflammation related to atherosclerosis in asymptomatic abdominal aortic aneurysm (AAA) patients. Methods. Thirty AAA patients and 30 age-matched controls underwent contrast-enhanced 2-deoxy-2-[18F]fluo-ro-D-glucose (FDG) PET/CT. C-reactive protein, erythrocyte sedimentation rate, white blood cell count and differential, serum fibrinogen, D-dimer and full lipid panel were also evaluated. Region of interest analyses were performed to obtain target-to-background (TBR) metabolism of aorta, subclavian, carotid, iliac arteries and AAA. CT-based arterial calcium load (CL) was evaluated. Arterial Metabolism and CL intergroup differences were tested (unpaired t-test). Linear regression analysis was performed only between blood biomarkers on one side and both TBR and ACL of the arterial districts that resulted significantly different between patients and controls on the other. In all the analyses P values
AB - Aim. The aim of this paper was to investigate the presence of systemic vascular inflammation and its relationship with risk factors and biomarkers of systemic inflammation related to atherosclerosis in asymptomatic abdominal aortic aneurysm (AAA) patients. Methods. Thirty AAA patients and 30 age-matched controls underwent contrast-enhanced 2-deoxy-2-[18F]fluo-ro-D-glucose (FDG) PET/CT. C-reactive protein, erythrocyte sedimentation rate, white blood cell count and differential, serum fibrinogen, D-dimer and full lipid panel were also evaluated. Region of interest analyses were performed to obtain target-to-background (TBR) metabolism of aorta, subclavian, carotid, iliac arteries and AAA. CT-based arterial calcium load (CL) was evaluated. Arterial Metabolism and CL intergroup differences were tested (unpaired t-test). Linear regression analysis was performed only between blood biomarkers on one side and both TBR and ACL of the arterial districts that resulted significantly different between patients and controls on the other. In all the analyses P values
KW - Abdominal
KW - Aortic aneurysm
KW - Atherosclerosis
KW - Positron-emission tomography
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M3 - Article
C2 - 24658166
AN - SCOPUS:84925227038
SN - 1824-4785
VL - 58
SP - 299
EP - 309
JO - Quarterly Journal of Nuclear Medicine and Molecular Imaging
JF - Quarterly Journal of Nuclear Medicine and Molecular Imaging
IS - 3
ER -