Synthesis of fluorescent PMMA-based nanoparticles

Marco Dossi, Raffaele Ferrari, Luca Dragoni, Carlotta Martignoni, Paolo Gaetani, Maurizio D'Incalci, Massimo Morbidelli, Davide Moscatelli

Research output: Contribution to journalArticlepeer-review


The synthesis of PMMA-based nanoparticles (NPs) covalently labeled with a fluorescent dye is investigated for imaging applications such as cell uptake and biodistribution. Batch emulsion polymerization (BEP) and monomer-starved semi-batch emulsion polymerization (MSSEP) are adopted using SDS. Fluorescent properties are added to these NPs using Rhodamine-B (RhB) as a fluorescent dye covalently bonded to 2-hyroxyethyl-acrylate. The resulting HEMA-RhB monomer is copolymerized with MMA via BEP and MSSEP to synthesize fluorescent NPs. Subsequently, SDS is substituted with a biocompatible surfactant, Tween80, through ionic-exchange resins. ζ-Potential measurements confirmed the complete surfactant exchange that leads to biocompatible fluorescent NPs with tunable size and narrow size distribution.

Original languageEnglish
Pages (from-to)771-778
Number of pages8
JournalMacromolecular Materials and Engineering
Issue number7
Publication statusPublished - Jul 2013


  • biocompatibility
  • biological applications of polymers
  • colloids
  • imaging
  • nanoparticles

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics
  • Chemical Engineering(all)


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