TY - JOUR
T1 - Synthesis and biological evaluation of azido- and aziridino-hydroxyl- β-lactams through stereo- and regioselective epoxide ring opening
AU - Benfatti, Fides
AU - Cardillo, Giuliana
AU - Gentilucci, Luca
AU - Perciaccante, Rossana
AU - Tolomelli, Alessandra
AU - Catapano, Alberico
PY - 2006/11/24
Y1 - 2006/11/24
N2 - (Chemical Equation Presented) Two new classes of azido- and aziridino-hydroxyl-β-lactam containing structures have been prepared by means of a stereo- and regioselective epoxide ring opening. The straightforwardness of the procedure makes this strategy useful for the synthesis of potentially bioactive compounds. Some selected examples showed promising activity in acyl CoA-cholesterol acyltransferase inhibition assays.
AB - (Chemical Equation Presented) Two new classes of azido- and aziridino-hydroxyl-β-lactam containing structures have been prepared by means of a stereo- and regioselective epoxide ring opening. The straightforwardness of the procedure makes this strategy useful for the synthesis of potentially bioactive compounds. Some selected examples showed promising activity in acyl CoA-cholesterol acyltransferase inhibition assays.
UR - http://www.scopus.com/inward/record.url?scp=33751584593&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33751584593&partnerID=8YFLogxK
U2 - 10.1021/jo0615652
DO - 10.1021/jo0615652
M3 - Article
C2 - 17109554
AN - SCOPUS:33751584593
SN - 0022-3263
VL - 71
SP - 9229
EP - 9232
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 24
ER -