Synovial sarcomas of the upper aero-digestive tract: is there a role for conservative surgery?

Alberto Paderno, Alessandro Gronchi, Cesare Piazza

Research output: Contribution to journalReview articlepeer-review


PURPOSE OF REVIEW: To present the current state of knowledge concerning the role of conservative surgery in the treatment of synovial sarcomas of the upper aero-digestive tract (UADT).

RECENT FINDINGS: The wider experience on synovial sarcomas involving the extremities and the results of retrospective reports focused on head and neck synovial sarcomas tend to justify a conservative surgical approach when dealing with tumors involving the UADT.

SUMMARY: UADT synovial sarcomas is an extremely rare clinical entity (only around 50 cases reported in the literature, with four more herein presented from our own surgical series), with no clear guidelines concerning its treatment. Resection should be aimed to an en-bloc removal of the tumor within uninvolved surgical margins. In fit patients, a conservative surgical approach should be preferred if it does not interfere with a complete resection and reasonable functional outcomes. Adjuvant treatments (radiotherapy and/or chemotherapy) are frequently needed in view of the aggressive behavior of such tumor, but they should be balanced according to patient's characteristics and tumor risk factors (grade, size, and previous treatments).

Original languageEnglish
Pages (from-to)94-101
Number of pages8
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Issue number2
Publication statusPublished - Apr 2018


  • Adult
  • Disease-Free Survival
  • Female
  • Head and Neck Neoplasms/mortality
  • Humans
  • Male
  • Minimally Invasive Surgical Procedures/methods
  • Neoplasm Invasiveness/pathology
  • Neoplasm Staging
  • Organ Sparing Treatments/methods
  • Prognosis
  • Quality of Life
  • Risk Assessment
  • Role
  • Sarcoma, Synovial/mortality
  • Survival Rate


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