TY - JOUR
T1 - SV40 enhances the risk of malignant mesothelioma among people exposed to asbestos
T2 - A molecular epidemiologic case-control study
AU - Cristaudo, Alfonso
AU - Foddis, Rudy
AU - Vivaldi, Agnese
AU - Buselli, Rodolfo
AU - Gattini, Vittorio
AU - Guglielmi, Giovanni
AU - Cosentino, Francesca
AU - Ottenga, Franco
AU - Ciancia, Eugenio
AU - Libener, Roberta
AU - Filiberti, Rosangela
AU - Neri, Monica
AU - Betta, PierGiacoino
AU - Tognon, Mauro
AU - Mutti, Luciano
AU - Puntoni, Riccardo
PY - 2005/4/15
Y1 - 2005/4/15
N2 - We conducted a case-control study on asbestos exposure and presence of SV40 in tumor samples of malignant mesotheliomas (MMs) and bladder urotheliomas (BUs). PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MMs and 6 (33.3%) BUs. The odds ratio for MM Asb- and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40- was 3.6 (95% CI, 0.6-21.0), and for Asb+ and SV40+ was 12.6 (95% CI, 1.2-133.9). Our results suggest that SV40 increases the risk of MM among individuals exposed to asbestos.
AB - We conducted a case-control study on asbestos exposure and presence of SV40 in tumor samples of malignant mesotheliomas (MMs) and bladder urotheliomas (BUs). PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MMs and 6 (33.3%) BUs. The odds ratio for MM Asb- and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40- was 3.6 (95% CI, 0.6-21.0), and for Asb+ and SV40+ was 12.6 (95% CI, 1.2-133.9). Our results suggest that SV40 increases the risk of MM among individuals exposed to asbestos.
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M3 - Article
C2 - 15833832
AN - SCOPUS:20244375557
SN - 0008-5472
VL - 65
SP - 3049
EP - 3052
JO - Journal of Cancer Research
JF - Journal of Cancer Research
IS - 8
ER -