Sural nerve immunoreactivity for nerve growth factor receptor in a case of localized hypertrophic neuropathy

M. Sciacco; E. Scarpini; P. L. Baron; R. Doronzo; M. Moggio; D. Passerini; G. Scarlato

doi:10.1007/BF00310035

Sural nerve immunoreactivity for nerve growth factor receptor in a case of localized hypertrophic neuropathy

M. Sciacco, E. Scarpini, P. L. Baron, R. Doronzo, M. Moggio, D. Passerini, G. Scarlato

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Immunoreactivity for nerve growth factor receptor (NGFR) was examined using a monoclonal antibody against human NGFR in the sural nerve of a 24-year-old woman, affected by localized hypertrophic neuropathy (LHN). NGFR expression was correlated with electron microscopy and with immunoreactivity for S-100 protein, laminin, HLA-DR, HNK-1, P0 glycoprotein and neurofilament peptides. Our results indicate that in LHN most of whorl-forming cells are NGFR positive and S-100 protein or HLA-DR negative. These data along with the ultrastructural features suggest their origin from perineurium.

Original language	English
Pages (from-to)	547-553
Number of pages	7
Journal	Acta Neuropathologica
Volume	83
Issue number	5
DOIs	https://doi.org/10.1007/BF00310035
Publication status	Published - Apr 1992

Keywords

Electron microscopy
Immunohistochemistry
Localized hypertrophic neuropathy
Nerve growth factor receptor
Schwann cells

ASJC Scopus subject areas

Neuroscience(all)
Pathology and Forensic Medicine
Clinical Neurology

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10.1007/BF00310035

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title = "Sural nerve immunoreactivity for nerve growth factor receptor in a case of localized hypertrophic neuropathy",

abstract = "Immunoreactivity for nerve growth factor receptor (NGFR) was examined using a monoclonal antibody against human NGFR in the sural nerve of a 24-year-old woman, affected by localized hypertrophic neuropathy (LHN). NGFR expression was correlated with electron microscopy and with immunoreactivity for S-100 protein, laminin, HLA-DR, HNK-1, P0 glycoprotein and neurofilament peptides. Our results indicate that in LHN most of whorl-forming cells are NGFR positive and S-100 protein or HLA-DR negative. These data along with the ultrastructural features suggest their origin from perineurium.",

keywords = "Electron microscopy, Immunohistochemistry, Localized hypertrophic neuropathy, Nerve growth factor receptor, Schwann cells",

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T1 - Sural nerve immunoreactivity for nerve growth factor receptor in a case of localized hypertrophic neuropathy

AU - Sciacco, M.

AU - Scarpini, E.

AU - Baron, P. L.

AU - Doronzo, R.

AU - Moggio, M.

AU - Passerini, D.

AU - Scarlato, G.

PY - 1992/4

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N2 - Immunoreactivity for nerve growth factor receptor (NGFR) was examined using a monoclonal antibody against human NGFR in the sural nerve of a 24-year-old woman, affected by localized hypertrophic neuropathy (LHN). NGFR expression was correlated with electron microscopy and with immunoreactivity for S-100 protein, laminin, HLA-DR, HNK-1, P0 glycoprotein and neurofilament peptides. Our results indicate that in LHN most of whorl-forming cells are NGFR positive and S-100 protein or HLA-DR negative. These data along with the ultrastructural features suggest their origin from perineurium.

AB - Immunoreactivity for nerve growth factor receptor (NGFR) was examined using a monoclonal antibody against human NGFR in the sural nerve of a 24-year-old woman, affected by localized hypertrophic neuropathy (LHN). NGFR expression was correlated with electron microscopy and with immunoreactivity for S-100 protein, laminin, HLA-DR, HNK-1, P0 glycoprotein and neurofilament peptides. Our results indicate that in LHN most of whorl-forming cells are NGFR positive and S-100 protein or HLA-DR negative. These data along with the ultrastructural features suggest their origin from perineurium.

KW - Electron microscopy

KW - Immunohistochemistry

KW - Localized hypertrophic neuropathy

KW - Nerve growth factor receptor

KW - Schwann cells

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Sural nerve immunoreactivity for nerve growth factor receptor in a case of localized hypertrophic neuropathy

Abstract

Keywords

ASJC Scopus subject areas

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