Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 354-361 |
| Journal | CNS Spectrums |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2021 |
Keywords
- Obsessive-compulsive disorder
- suicidality
- tic disorder
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Suicidal ideation and suicidal attempts in patients with obsessive-compulsive tic-related disorder vs obsessive-compulsive disorder: Results of a multicenter Italian study. / Benatti, B.; Ferrari, S.; Grancini, B. et al.
In: CNS Spectrums, Vol. 26, No. 4, 08.2021, p. 354-361.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Suicidal ideation and suicidal attempts in patients with obsessive-compulsive tic-related disorder vs obsessive-compulsive disorder: Results of a multicenter Italian study
AU - Benatti, B.
AU - Ferrari, S.
AU - Grancini, B.
AU - Girone, N.
AU - Briguglio, M.
AU - Marazziti, D.
AU - Mucci, F.
AU - Dell'Osso, L.
AU - Gambini, O.
AU - Demartini, B.
AU - Tundo, A.
AU - Necci, R.
AU - De Berardis, D.
AU - Galentino, R.
AU - De Michele, S.
AU - Albert, U.
AU - Rigardetto, S.
AU - Maina, G.
AU - Grassi, G.
AU - Pallanti, S.
AU - Amerio, A.
AU - Amore, M.
AU - Priori, A.
AU - Servello, D.
AU - Viganò, C.
AU - Bosi, M.
AU - Colombo, A.
AU - Porta, M.
AU - Dell'Osso, B.
N1 - Cited By :2 Export Date: 24 February 2021 CODEN: CNSPF Correspondence Address: Benatti, B.; Luigi Sacco University Hospital, Italy; email: beatricebenatti@gmail.com References: Dell'Osso, B., Benatti, B., Hollander, E., Socio-demographic and clinical characterization of patients with obsessive-compulsive tic-related disorder (OCTD): An Italian multicenter study (2018) J Psychopathol, 24 (3), pp. 148-153; (2013) Diagnostic and Statistical Manual of Mental Disorders, , American Psychiatric Association. 5th ed. Arlington, VA: American Psychiatric Association; Zohar, J., OCD: Towards DSM-V (2007) Int J Psychiatry Clin Pract, 11 (SUPPL 2), pp. 1-4; Kloft, L., Steinel, T., Kathmann, N., Systematic review of co-occurring OCD and TD: Evidence for a tic-related OCD subtype? (2018) Neurosci Biobehav Rev, 95, pp. 280-314; Pinto, R., Monzani, B., Leckman, J.F., Understanding the covariation of tics, attention-deficit/hyperactivity, and obsessive-compulsive symptoms: A population-based adult twin study (2016) Am J Med Genet B Neuropsychiatr Genet, 171 (7), pp. 938-947; Yu, D., Mathews, C.A., Scharf, J.M., Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD (2015) Am J Psychiatry, 172 (1), pp. 82-93; Dell'Osso, B., Marazziti, D., Albert, U., Parsing the phenotype of obsessive-compulsive tic disorder (OCTD): A multidisciplinary consensus (2017) Int J Psychiatry Clin Pract, 21 (2), pp. 156-159; Amerio, A., Stubbs, B., Odone, A., Tonna, M., Marchesi, C., Ghaemi, S.N., Bipolar i and II disorders: A systematic review and meta-analysis on differences in comorbid obsessive-compulsive disorder (2016) Iran J Psychiatry Behav Sci, 10 (3). , e3604; Angelakis, I., Gooding, P., Tarrier, N., Panagioti, M., Suicidality in obsessive compulsive disorder (OCD): A systematic review and meta-analysis (2015) Clin Psychol Rev, 39, pp. 1-15; Angelakis, I., Gooding, P., Obsessive-compulsive disorder and suicidal experiences: The role of experiential avoidance (2019) Suicide Life Threat Behav, , http://www.ncbi.nlm.nih.gov/pubmed/31553082; Fernández De La Cruz, L., Rydell, M., Runeson, B., Suicide in Tourette's and chronic tic disorders (2017) Biol Psychiatry, 82 (2), pp. 111-118; Albert, U., De Ronchi, D., Maina, G., Pompili, M., Suicide risk in obsessive-compulsive disorder and exploration of risk factors: A systematic review (2019) Curr Neuropharmacol, 17 (8), pp. 681-696; Kamath, P., Reddy, Y.C.J., Kandavel, T., Suicidal behavior in obsessive-compulsive disorder (2007) J Clin Psychiatry, 68 (11), pp. 1741-1750; Velloso, P., Piccinato, C., Ferrão, Y., The suicidality continuum in a large sample of obsessive-compulsive disorder (OCD) patients (2016) Eur Psychiatry, 38, pp. 1-7; Narayanaswamy, J.C., Viswanath, B., Veshnal Cherian, A., Bada Math, S., Kandavel, T., Janardhan Reddy, Y.C., Impact of age of onset of illness on clinical phenotype in OCD (2012) Psychiatry Res, 200 (2-3), pp. 554-559; First, M.B., Spitzer, R.L., Gibbon, M., Williams, J.B., (2002) Structured Clinical Interview for DSM-IV-TR Axis i Disorders, Research Version, Patient Edition (SCID-I/P), , New York, NY: New York Biometrics Research; First, M., Gibbon, M., Spitzer, R., Williams, J., Benjamin, L., (1997) Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II), , Washington DC: American Psychiatric Press; Goodman, W.K., Price, L.H., Rasmussen, S.A., The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability (1989) Arch Gen Psychiatry, 46 (11), pp. 1006-1011; Roessner, V., Becker, A., Banaschewski, T., Rothenberger, A., Tic disorders and obsessive compulsive disorder: Where is the link? (2005) J Neural Transm Suppl, (69), pp. 69-99; Storch, E.A., Hanks, C.E., Mink, J.W., Suicidal thoughts and behaviors in children and adolescents with chronic tic disorders (2015) Depress Anxiety, 32 (10), pp. 744-753; Dell'Osso, B., Benatti, B., Arici, C., Prevalence of suicide attempt and clinical characteristics of suicide attempters with obsessive-compulsive disorder: A report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) (2018) CNS Spectr, 23 (1), pp. 59-66; Alonso, P., Segalàs, C., Real, E., Suicide in patients treated for obsessive-compulsive disorder: A prospective follow-up study (2010) J Affect Disord, 124 (3), pp. 300-308; Balci, V., Sevincok, L., Suicidal ideation in patients with obsessive-compulsive disorder (2010) Psychiatry Res, 175 (1-2), pp. 104-108; Fontenelle, I.S., Fontenelle, L.F., Borges, M.C., Quality of life and symptom dimensions of patients with obsessive-compulsive disorder (2010) Psychiatry Res, 179 (2), pp. 198-203; Moritz, S., A review on quality of life and depression in obsessive-compulsive disorder (2008) CNS Spectr, 13 (9 SUPPL 14), pp. 16-22; Taylor, S., Early versus late onset obsessive-compulsive disorder: Evidence for distinct subtypes (2011) Clin Psychol Rev, 31 (7), pp. 1083-1100; De Mathis, M.A., Diniz, J.B., Hounie, A.G., Trajectory in obsessive-compulsive disorder comorbidities (2013) Eur Neuropsychopharmacol, 23 (7), pp. 594-601; Fernández De La Cruz, L., Rydell, M., Runeson, B., Suicide in obsessive-compulsive disorder: A population-based study of 36 788 Swedish patients (2016) Mol Psychiatry, 22, pp. 1-7; Walsh, K.H., McDougle, C.J., Psychotherapy and medication management strategies for obsessive-compulsive disorder (2011) Neuropsychiatr Dis Treat, 7, pp. 485-494; Hantouche, E.G., Demonfaucon, C., Toc résistant: Caractéristiques cliniques, facteurs prédictifs et influence des tempéraments affectifs (2008) Encephale, 34 (6), pp. 611-617; Erbuto, D., Innamorati, M., Lamis, D.A., Mediators in the association between affective temperaments and suicide risk among psychiatric inpatients (2018) Psychiatry, 81 (3), pp. 240-257; Akiskal, H.S., Akiskal, K.K., Haykal, R.F., Manning, J.S., Connor, P.D., TEMPS-A: Progress towards validation of a self-rated clinical version of the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire (2005) J Affect Disord, 85 (1-2), pp. 3-16; Beck, A.T., Weissman, A., Lester, D., Trexler, L., The measurement of pessimism: The Hopelessness Scale (1974) J Consult Clin Psychol, 42 (6), pp. 861-865; Shneidman, E.S., The psychological pain assessment scale (1999) Suicide Life Threat Behav, 29 (4), pp. 287-294; Hausberg, M.C., Schulz, H., Piegler, T., Is a self-rated instrument appropriate to assess mentalization in patients with mental disorders? Development and first validation of the mentalization questionnaire (MZQ) (2012) Psychother Res, 22 (6), pp. 699-709; Silverman, M.M., Berman, A.L., Sanddal, N.D., O'Carroll, P.W., Joiner, T.E., Rebuilding the Tower of Babel: A revised nomenclature for the Study of Suicide and Suicidal Behaviors Part 2: Suicide-related ideations (2007) Commun Behav Suicide Life-Threatening Behav, 37 (3), pp. 264-277
PY - 2021/8
Y1 - 2021/8
N2 - Background.Obsessive-compulsive disorder (OCD) and tic disorder (TD) represent highly disabling, chronic and often comorbid psychiatric conditions. While recent studies showed a high risk of suicide for patients with OCD, little is known about those patients with comorbid TD (OCTD). Aim of this study was to characterize suicidal behaviors among patients with OCD and OCTD.Methods.Three hundred and thirteen outpatients with OCD (n = 157) and OCTD (n = 156) were recruited from nine different psychiatric Italian departments and assessed using an ad-hoc developed questionnaire investigating, among other domains, suicide attempt (SA) and ideation (SI). The sample was divided into four subgroups: OCD with SA (OCD-SA), OCD without SA (OCD-noSA), OCTD with SA (OCTD-SA), and OCTD without SA (OCTD-noSA).Results.No differences between groups were found in terms of SI, while SA rates were significantly higher in patients with OCTD compared to patients with OCD. OCTD-SA group showed a significant male prevalence and higher unemployment rates compared to OCD-SA and OCD-noSA sample. Both OCTD-groups showed an earlier age of psychiatric comorbidity onset (other than TD) compared to the OCD-SA sample. Moreover, patients with OCTD-SA showed higher rates of other psychiatric comorbidities and positive psychiatric family history compared to the OCD-SA group and to the OCD-noSA groups. OCTD-SA and OCD-SA samples showed higher rates of antipsychotics therapies and treatment resistance compared to OCD-noSA groups.Conclusions.Patients with OCTD vs with OCD showed a significantly higher rate of SA with no differences in SI. In particular, OCTD-SA group showed different unfavorable epidemiological and clinical features which need to be confirmed in future prospective studies. © The Author(s) 2020. Published by Cambridge University Press.
AB - Background.Obsessive-compulsive disorder (OCD) and tic disorder (TD) represent highly disabling, chronic and often comorbid psychiatric conditions. While recent studies showed a high risk of suicide for patients with OCD, little is known about those patients with comorbid TD (OCTD). Aim of this study was to characterize suicidal behaviors among patients with OCD and OCTD.Methods.Three hundred and thirteen outpatients with OCD (n = 157) and OCTD (n = 156) were recruited from nine different psychiatric Italian departments and assessed using an ad-hoc developed questionnaire investigating, among other domains, suicide attempt (SA) and ideation (SI). The sample was divided into four subgroups: OCD with SA (OCD-SA), OCD without SA (OCD-noSA), OCTD with SA (OCTD-SA), and OCTD without SA (OCTD-noSA).Results.No differences between groups were found in terms of SI, while SA rates were significantly higher in patients with OCTD compared to patients with OCD. OCTD-SA group showed a significant male prevalence and higher unemployment rates compared to OCD-SA and OCD-noSA sample. Both OCTD-groups showed an earlier age of psychiatric comorbidity onset (other than TD) compared to the OCD-SA sample. Moreover, patients with OCTD-SA showed higher rates of other psychiatric comorbidities and positive psychiatric family history compared to the OCD-SA group and to the OCD-noSA groups. OCTD-SA and OCD-SA samples showed higher rates of antipsychotics therapies and treatment resistance compared to OCD-noSA groups.Conclusions.Patients with OCTD vs with OCD showed a significantly higher rate of SA with no differences in SI. In particular, OCTD-SA group showed different unfavorable epidemiological and clinical features which need to be confirmed in future prospective studies. © The Author(s) 2020. Published by Cambridge University Press.
KW - Obsessive-compulsive disorder
KW - suicidality
KW - tic disorder
U2 - 10.1017/S1092852920001157
DO - 10.1017/S1092852920001157
M3 - Article
SN - 1092-8529
VL - 26
SP - 354
EP - 361
JO - CNS Spectrums
JF - CNS Spectrums
IS - 4
ER -