TY - JOUR
T1 - Successful Imatinib Treatment for Systemic Mastocytosis Associated With Myelodysplastic/Myeloproliferative Neoplasm
T2 - Report of a Case and Literature Review
AU - Barozzi, Enrico
AU - Bucelli, Cristina
AU - Grifoni, Federica Irene
AU - Gianelli, Umberto
AU - Iurlo, Alessandra
AU - Cattaneo, Daniele
N1 - Publisher Copyright:
Copyright © 2022 Barozzi, Bucelli, Grifoni, Gianelli, Iurlo and Cattaneo.
PY - 2022/1/12
Y1 - 2022/1/12
N2 - Systemic mastocytosis (SM) is a heterogeneous disease characterized by the expansion of mast cells in one or more tissues, frequently characterized by the presence of KITD816V mutation. The updated World Health Organization (WHO) classification of myeloid neoplasms recognizes SM with an associated hematological neoplasm (SM-AHN) as a new subtype among the others, which is depicted by the coexistence of SM with another hematological clonal disease. Prognosis is very different among SM patients, while its treatment, although highly personalized, is still challenging. Here we report a case of KITD816V-unmutated SM associated with MDS/MPN successfully treated with imatinib.
AB - Systemic mastocytosis (SM) is a heterogeneous disease characterized by the expansion of mast cells in one or more tissues, frequently characterized by the presence of KITD816V mutation. The updated World Health Organization (WHO) classification of myeloid neoplasms recognizes SM with an associated hematological neoplasm (SM-AHN) as a new subtype among the others, which is depicted by the coexistence of SM with another hematological clonal disease. Prognosis is very different among SM patients, while its treatment, although highly personalized, is still challenging. Here we report a case of KITD816V-unmutated SM associated with MDS/MPN successfully treated with imatinib.
KW - imatinib
KW - MDS/MPN
KW - myeloid neoplasms
KW - SM-AHN
KW - systemic mastocytosis
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UR - http://www.scopus.com/inward/citedby.url?scp=85123428465&partnerID=8YFLogxK
U2 - 10.3389/fonc.2021.819097
DO - 10.3389/fonc.2021.819097
M3 - Article
AN - SCOPUS:85123428465
SN - 2234-943X
VL - 11
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 819097
ER -