Successful antiretroviral therapy by using unusual antiretroviral combinations in heavily pre-treated patients: two case reports

Lucia Taramasso; Chiara Dentone; Anna Alessandrini; Bianca Bruzzone; Giancarlo Icardi; Rodolphe Garraffo; Ilaria De Macina; Claudio Viscoli; Antonio Di Biagio

doi:10.1177/0956462414556330

Successful antiretroviral therapy by using unusual antiretroviral combinations in heavily pre-treated patients: two case reports

Lucia Taramasso, Chiara Dentone, Anna Alessandrini, Bianca Bruzzone, Giancarlo Icardi, Rodolphe Garraffo, Ilaria De Macina, Claudio Viscoli, Antonio Di Biagio

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

In the context of HIV-infected patients with several past antiretroviral therapies and multiple failures, it is possible to be faced with viruses resistant to all drug classes. We report on two HIV-1 infected patients in which the historical genotype showed mutations against all the major drug classes and in which viral suppression has been obtained by non-conventional antiretroviral therapy regimens, including the combination of darunavir at high dosage (800 mg bid), dolutegravir (50 mg bid) and a third agent, i.e. enfuvirtide in the first case and etravirine in the second one.

Original language	English
Pages (from-to)	831-834
Number of pages	4
Journal	International Journal of STD and AIDS
Volume	26
Issue number	11
DOIs	https://doi.org/10.1177/0956462414556330
Publication status	Published - Oct 24 2015

Keywords

AIDS
antiretroviral therapy
darunavir
dolutegravir
HIV
resistance
treatment
treatment experienced

ASJC Scopus subject areas

Dermatology
Public Health, Environmental and Occupational Health
Pharmacology (medical)
Infectious Diseases
Medicine(all)

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10.1177/0956462414556330

Cite this

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abstract = "In the context of HIV-infected patients with several past antiretroviral therapies and multiple failures, it is possible to be faced with viruses resistant to all drug classes. We report on two HIV-1 infected patients in which the historical genotype showed mutations against all the major drug classes and in which viral suppression has been obtained by non-conventional antiretroviral therapy regimens, including the combination of darunavir at high dosage (800 mg bid), dolutegravir (50 mg bid) and a third agent, i.e. enfuvirtide in the first case and etravirine in the second one.",

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AU - Taramasso, Lucia

AU - Dentone, Chiara

AU - Alessandrini, Anna

AU - Bruzzone, Bianca

AU - Icardi, Giancarlo

AU - Garraffo, Rodolphe

AU - De Macina, Ilaria

AU - Viscoli, Claudio

AU - Di Biagio, Antonio

PY - 2015/10/24

Y1 - 2015/10/24

N2 - In the context of HIV-infected patients with several past antiretroviral therapies and multiple failures, it is possible to be faced with viruses resistant to all drug classes. We report on two HIV-1 infected patients in which the historical genotype showed mutations against all the major drug classes and in which viral suppression has been obtained by non-conventional antiretroviral therapy regimens, including the combination of darunavir at high dosage (800 mg bid), dolutegravir (50 mg bid) and a third agent, i.e. enfuvirtide in the first case and etravirine in the second one.

AB - In the context of HIV-infected patients with several past antiretroviral therapies and multiple failures, it is possible to be faced with viruses resistant to all drug classes. We report on two HIV-1 infected patients in which the historical genotype showed mutations against all the major drug classes and in which viral suppression has been obtained by non-conventional antiretroviral therapy regimens, including the combination of darunavir at high dosage (800 mg bid), dolutegravir (50 mg bid) and a third agent, i.e. enfuvirtide in the first case and etravirine in the second one.

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KW - resistance

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Successful antiretroviral therapy by using unusual antiretroviral combinations in heavily pre-treated patients: two case reports

Abstract

Keywords

ASJC Scopus subject areas

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