Sublingual immunotherapy in children with allergic polysensitization

Giorgio Ciprandi, Geovanni Cadario, Giuseppe M. Di Gioacchino, Salvatore Gangemi, Alberto Gasparini, S. Isola, Fulvia Marengo, Salvatore Minelli, Leopoldo Ricciardi, Erminia Ridolo, Valerio Pravettoni, Carla Valle, Marcello Verini, Marcello Zambito, Cristoforo Incorvaia, Paola Puccinelli, Silvia Scurati, Franco Frati, Simonetta Masier

Research output: Contribution to journalArticlepeer-review


Polysensitization is quite frequent in allergic children and may cause difficulties for the allergist in prescribing allergenspecific immunotherapy. This study aimed at evaluating the clinical effectiveness of 1 year of sublingual immunotherapy (SLIT) in a cohort of Italian allergic children with polysensitization. This open study was performed on 51 polysensitized children (34 boys; mean age, 11.8 years; range, 5.2-17.7 years) with allergic rhinitis and/or mild to moderate asthma. All of them were treated with SLIT for 1 year. The kind and the number of prescribed allergen extracts, the type of diagnosis, the severity of symptoms, and the use of drugs were evaluated at baseline and after 1 year. The adverse events to SLIT were also evaluated. Forty-two children were treated with a single extract, four with two different extracts and three with a mix of allergens. SLIT treatment induced a significant reduction in the number of sensitizations (p = 0.018); significant improvement of allergic rhinitis classification and severity; significant reduction of ocular, nasal, and bronchial symptoms (p <0.01 for all); and drugs use (p <0.01 for all drugs). No systemic reactions to SLIT were observed. This open study provides evidence that polysensitization is not an obstacle for prescribing SLIT in polysensitized children. Indeed, SLIT efficacy on clinical parameters is significant after 1 year and the therapy is safe.

Original languageEnglish
Pages (from-to)227-231
Number of pages5
JournalAllergy and Asthma Proceedings
Issue number3
Publication statusPublished - May 2010


  • Allergic rhinitis
  • Asthma
  • Children
  • Classification and severity
  • Sublingual immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


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