Subacute combined degeneration without nutritional anemia

M. Miscusi; L. Testaverde; A. Rago; A. Raco; C. Colonnese

doi:10.1016/j.jocn.2012.01.039

Subacute combined degeneration without nutritional anemia

M. Miscusi, L. Testaverde, A. Rago, A. Raco, C. Colonnese

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Abstract

Subacute combined degeneration (SCD) is a rare neurological complication of cobalamin deficiency, characterized by demyelination of the dorsal and lateral spinal cord. The diagnosis and treatment of SCD can be delayed if a patient does not present with clear clinical and laboratory signs of nutritional anemia, which has a marked effect on neurological recovery. We report a 62-year-old man with SCD with a history of gastric cancer and chronic alcoholism who presented with ataxia, gait disturbance, urinary incontinence, and limb weakness, but without other clinical or laboratory signs of cobalamin deficiency. The SCD diagnosis was confirmed by 3-Tesla MRI, which showed intramedullary signal alteration in the posterior columns of the entire spinal cord.

Original language	English
Pages (from-to)	1744-1745
Number of pages	2
Journal	Journal of Clinical Neuroscience
Volume	19
Issue number	12
DOIs	https://doi.org/10.1016/j.jocn.2012.01.039
Publication status	Published - Dec 2012

Keywords

Cobalamin deficiency
Demyelination
Spinal cord

ASJC Scopus subject areas

Clinical Neurology
Neurology
Physiology (medical)

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10.1016/j.jocn.2012.01.039

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abstract = "Subacute combined degeneration (SCD) is a rare neurological complication of cobalamin deficiency, characterized by demyelination of the dorsal and lateral spinal cord. The diagnosis and treatment of SCD can be delayed if a patient does not present with clear clinical and laboratory signs of nutritional anemia, which has a marked effect on neurological recovery. We report a 62-year-old man with SCD with a history of gastric cancer and chronic alcoholism who presented with ataxia, gait disturbance, urinary incontinence, and limb weakness, but without other clinical or laboratory signs of cobalamin deficiency. The SCD diagnosis was confirmed by 3-Tesla MRI, which showed intramedullary signal alteration in the posterior columns of the entire spinal cord.",

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AU - Miscusi, M.

AU - Testaverde, L.

AU - Rago, A.

AU - Raco, A.

AU - Colonnese, C.

PY - 2012/12

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AB - Subacute combined degeneration (SCD) is a rare neurological complication of cobalamin deficiency, characterized by demyelination of the dorsal and lateral spinal cord. The diagnosis and treatment of SCD can be delayed if a patient does not present with clear clinical and laboratory signs of nutritional anemia, which has a marked effect on neurological recovery. We report a 62-year-old man with SCD with a history of gastric cancer and chronic alcoholism who presented with ataxia, gait disturbance, urinary incontinence, and limb weakness, but without other clinical or laboratory signs of cobalamin deficiency. The SCD diagnosis was confirmed by 3-Tesla MRI, which showed intramedullary signal alteration in the posterior columns of the entire spinal cord.

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KW - Demyelination

KW - Spinal cord

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Subacute combined degeneration without nutritional anemia

Abstract

Keywords

ASJC Scopus subject areas

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