Subacute combined degeneration without nutritional anemia

M. Miscusi, L. Testaverde, A. Rago, A. Raco, C. Colonnese

Research output: Contribution to journalArticlepeer-review


Subacute combined degeneration (SCD) is a rare neurological complication of cobalamin deficiency, characterized by demyelination of the dorsal and lateral spinal cord. The diagnosis and treatment of SCD can be delayed if a patient does not present with clear clinical and laboratory signs of nutritional anemia, which has a marked effect on neurological recovery. We report a 62-year-old man with SCD with a history of gastric cancer and chronic alcoholism who presented with ataxia, gait disturbance, urinary incontinence, and limb weakness, but without other clinical or laboratory signs of cobalamin deficiency. The SCD diagnosis was confirmed by 3-Tesla MRI, which showed intramedullary signal alteration in the posterior columns of the entire spinal cord.

Original languageEnglish
Pages (from-to)1744-1745
Number of pages2
JournalJournal of Clinical Neuroscience
Issue number12
Publication statusPublished - Dec 2012


  • Cobalamin deficiency
  • Demyelination
  • Spinal cord

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)


Dive into the research topics of 'Subacute combined degeneration without nutritional anemia'. Together they form a unique fingerprint.

Cite this