Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy

R. Lodi, G. Pierangeli, C. Tonon, S. Cevoli, C. Testa, G. Bivona, F. Magnifico, P. Cortelli, P. Montagna, B. Barbiroli

Research output: Contribution to journalArticlepeer-review


The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p <0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.

Original languageEnglish
Pages (from-to)1264-1266
Number of pages3
Issue number8
Publication statusPublished - Apr 2006

ASJC Scopus subject areas

  • Neuroscience(all)


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