Stress and ano-colorectal surgery in newborn/infant: Role of anesthesia

P. Bozza, F. Morini, A. Conforti, S. Sgro, R. Laviani Mancinelli, S. Ottino, P. Bagolan, S. Picardo

Research output: Contribution to journalArticlepeer-review


Purpose The best anesthesia for newborns/infants necessitating colorectal surgery remains questionable. Endovenous and locoregional anesthesiological approaches were compared to determine the influence on stress response. Methods Patients with anorectal malformations or Hirschsprung's disease were randomized to inhalatory/epidural anesthesia (IPA) or inhalatory/endovenous anesthesia (IEA). Heart rate, blood pressure, oxygen saturation, serum concentrations of dehydroepiandrosterone, cortisol, and glucose were recorded 24 h before operation (T0), after tracheal intubation (T1), 120 min after skin incision (T2), 60 min (T3) and 24 h after operation (T4). Results Seventeen patients were enrolled in the study, 8 receiving IPA, and 9 IEA. Heart rate, blood pressure, oxygen saturation remained stable and normal, without statistical differences between the two groups, during the study period. Similar cortisol and glucose levels showed no statistical differences between groups. Dehydroepiandrosterone values were significantly higher in IEA during anesthesia (T1-T3) compared with IPA (T1: 494.0 vs. 266.5, p

Original languageEnglish
Pages (from-to)821-824
Number of pages4
JournalPediatric Surgery International
Issue number8
Publication statusPublished - Aug 2012


  • Colorectal surgery
  • Endovenous anesthesia
  • Epidural anesthesia
  • Stress

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery


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