TY - JOUR
T1 - Stress and ano-colorectal surgery in newborn/infant
T2 - Role of anesthesia
AU - Bozza, P.
AU - Morini, F.
AU - Conforti, A.
AU - Sgro, S.
AU - Laviani Mancinelli, R.
AU - Ottino, S.
AU - Bagolan, P.
AU - Picardo, S.
PY - 2012/8
Y1 - 2012/8
N2 - Purpose The best anesthesia for newborns/infants necessitating colorectal surgery remains questionable. Endovenous and locoregional anesthesiological approaches were compared to determine the influence on stress response. Methods Patients with anorectal malformations or Hirschsprung's disease were randomized to inhalatory/epidural anesthesia (IPA) or inhalatory/endovenous anesthesia (IEA). Heart rate, blood pressure, oxygen saturation, serum concentrations of dehydroepiandrosterone, cortisol, and glucose were recorded 24 h before operation (T0), after tracheal intubation (T1), 120 min after skin incision (T2), 60 min (T3) and 24 h after operation (T4). Results Seventeen patients were enrolled in the study, 8 receiving IPA, and 9 IEA. Heart rate, blood pressure, oxygen saturation remained stable and normal, without statistical differences between the two groups, during the study period. Similar cortisol and glucose levels showed no statistical differences between groups. Dehydroepiandrosterone values were significantly higher in IEA during anesthesia (T1-T3) compared with IPA (T1: 494.0 vs. 266.5, p
AB - Purpose The best anesthesia for newborns/infants necessitating colorectal surgery remains questionable. Endovenous and locoregional anesthesiological approaches were compared to determine the influence on stress response. Methods Patients with anorectal malformations or Hirschsprung's disease were randomized to inhalatory/epidural anesthesia (IPA) or inhalatory/endovenous anesthesia (IEA). Heart rate, blood pressure, oxygen saturation, serum concentrations of dehydroepiandrosterone, cortisol, and glucose were recorded 24 h before operation (T0), after tracheal intubation (T1), 120 min after skin incision (T2), 60 min (T3) and 24 h after operation (T4). Results Seventeen patients were enrolled in the study, 8 receiving IPA, and 9 IEA. Heart rate, blood pressure, oxygen saturation remained stable and normal, without statistical differences between the two groups, during the study period. Similar cortisol and glucose levels showed no statistical differences between groups. Dehydroepiandrosterone values were significantly higher in IEA during anesthesia (T1-T3) compared with IPA (T1: 494.0 vs. 266.5, p
KW - Colorectal surgery
KW - Endovenous anesthesia
KW - Epidural anesthesia
KW - Stress
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U2 - 10.1007/s00383-012-3126-2
DO - 10.1007/s00383-012-3126-2
M3 - Article
C2 - 22832839
AN - SCOPUS:84866040757
SN - 0179-0358
VL - 28
SP - 821
EP - 824
JO - Pediatric Surgery International
JF - Pediatric Surgery International
IS - 8
ER -