Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: A multicentre international study

Palak J. Trivedi; Willem J. Lammers; Henk R. Van Buuren; Albert Parés; Annarosa Floreani; Harry L A Janssen; Pietro Invernizzi; Pier Maria Battezzati; Cyriel Y. Ponsioen; Christophe Corpechot; Raoul Poupon; Marlyn J. Mayo; Andrew K. Burroughs; Frederik Nevens; Andrew L. Mason; Kris V. Kowdley; Ana Lleo; Llorenç Caballeria; Keith D. Lindor; Bettina E. Hansen; Gideon M. Hirschfield

doi:10.1136/gutjnl-2014-308351

Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: A multicentre international study

Palak J. Trivedi, Willem J. Lammers, Henk R. Van Buuren, Albert Parés, Annarosa Floreani, Harry L A Janssen, Pietro Invernizzi, Pier Maria Battezzati, Cyriel Y. Ponsioen, Christophe Corpechot, Raoul Poupon, Marlyn J. Mayo, Andrew K. Burroughs, Frederik Nevens, Andrew L. Mason, Kris V. Kowdley, Ana Lleo, Llorenç Caballeria, Keith D. Lindor, Bettina E. HansenGideon M. Hirschfield

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Objective Hepatocellular carcinoma (HCC) is an infrequent yet critical event in primary biliary cirrhosis (PBC); however, predictive tools remain ill-defined. Our objective was to identify candidate risk factors for HCC development in patients with PBC. Design Risk factor analysis was performed in over 15 centres from North America and Europe spanning >40 years observation period using Cox proportional hazards assumptions, logistic regression, and Kaplan- Meier estimates. Results Of 4565 patients with PBC 123 developed HCC, yielding an incidence rate (IR) of 3.4 cases/1000 patient-years. HCC was significantly more common in men (p

Original language	English
Pages (from-to)	321-329
Number of pages	9
Journal	Gut
Volume	65
Issue number	2
DOIs	https://doi.org/10.1136/gutjnl-2014-308351
Publication status	Published - Feb 1 2016

ASJC Scopus subject areas

Gastroenterology

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10.1136/gutjnl-2014-308351

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Trivedi, P. J., Lammers, W. J., Van Buuren, H. R., Parés, A., Floreani, A., Janssen, H. L. A., Invernizzi, P., Battezzati, P. M., Ponsioen, C. Y., Corpechot, C., Poupon, R., Mayo, M. J., Burroughs, A. K., Nevens, F., Mason, A. L., Kowdley, K. V., Lleo, A., Caballeria, L., Lindor, K. D., ... Hirschfield, G. M. (2016). Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: A multicentre international study. Gut, 65(2), 321-329. https://doi.org/10.1136/gutjnl-2014-308351

Trivedi, PJ, Lammers, WJ, Van Buuren, HR, Parés, A, Floreani, A, Janssen, HLA, Invernizzi, P, Battezzati, PM, Ponsioen, CY, Corpechot, C, Poupon, R, Mayo, MJ, Burroughs, AK, Nevens, F, Mason, AL, Kowdley, KV, Lleo, A, Caballeria, L, Lindor, KD, Hansen, BE & Hirschfield, GM 2016, 'Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: A multicentre international study', Gut, vol. 65, no. 2, pp. 321-329. https://doi.org/10.1136/gutjnl-2014-308351

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title = "Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: A multicentre international study",

abstract = "Objective Hepatocellular carcinoma (HCC) is an infrequent yet critical event in primary biliary cirrhosis (PBC); however, predictive tools remain ill-defined. Our objective was to identify candidate risk factors for HCC development in patients with PBC. Design Risk factor analysis was performed in over 15 centres from North America and Europe spanning >40 years observation period using Cox proportional hazards assumptions, logistic regression, and Kaplan- Meier estimates. Results Of 4565 patients with PBC 123 developed HCC, yielding an incidence rate (IR) of 3.4 cases/1000 patient-years. HCC was significantly more common in men (p",

author = "Trivedi, {Palak J.} and Lammers, {Willem J.} and {Van Buuren}, {Henk R.} and Albert Par{\'e}s and Annarosa Floreani and Janssen, {Harry L A} and Pietro Invernizzi and Battezzati, {Pier Maria} and Ponsioen, {Cyriel Y.} and Christophe Corpechot and Raoul Poupon and Mayo, {Marlyn J.} and Burroughs, {Andrew K.} and Frederik Nevens and Mason, {Andrew L.} and Kowdley, {Kris V.} and Ana Lleo and Lloren{\c c} Caballeria and Lindor, {Keith D.} and Hansen, {Bettina E.} and Hirschfield, {Gideon M.}",

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doi = "10.1136/gutjnl-2014-308351",

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T1 - Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis

T2 - A multicentre international study

AU - Trivedi, Palak J.

AU - Lammers, Willem J.

AU - Van Buuren, Henk R.

AU - Parés, Albert

AU - Floreani, Annarosa

AU - Janssen, Harry L A

AU - Invernizzi, Pietro

AU - Battezzati, Pier Maria

AU - Ponsioen, Cyriel Y.

AU - Corpechot, Christophe

AU - Poupon, Raoul

AU - Mayo, Marlyn J.

AU - Burroughs, Andrew K.

AU - Nevens, Frederik

AU - Mason, Andrew L.

AU - Kowdley, Kris V.

AU - Lleo, Ana

AU - Caballeria, Llorenç

AU - Lindor, Keith D.

AU - Hansen, Bettina E.

AU - Hirschfield, Gideon M.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Objective Hepatocellular carcinoma (HCC) is an infrequent yet critical event in primary biliary cirrhosis (PBC); however, predictive tools remain ill-defined. Our objective was to identify candidate risk factors for HCC development in patients with PBC. Design Risk factor analysis was performed in over 15 centres from North America and Europe spanning >40 years observation period using Cox proportional hazards assumptions, logistic regression, and Kaplan- Meier estimates. Results Of 4565 patients with PBC 123 developed HCC, yielding an incidence rate (IR) of 3.4 cases/1000 patient-years. HCC was significantly more common in men (p

AB - Objective Hepatocellular carcinoma (HCC) is an infrequent yet critical event in primary biliary cirrhosis (PBC); however, predictive tools remain ill-defined. Our objective was to identify candidate risk factors for HCC development in patients with PBC. Design Risk factor analysis was performed in over 15 centres from North America and Europe spanning >40 years observation period using Cox proportional hazards assumptions, logistic regression, and Kaplan- Meier estimates. Results Of 4565 patients with PBC 123 developed HCC, yielding an incidence rate (IR) of 3.4 cases/1000 patient-years. HCC was significantly more common in men (p

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Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: A multicentre international study

Abstract

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