Straightforward synthesis of novel Akt inhibitors based on a glucose scaffold

Laura Cipolla, Cristina Redaelli, Francesca Granucci, Giuseppe Zampella, Antonio Zaza, Riccardo Chisci, Francesco Nicotra

Research output: Contribution to journalArticlepeer-review


Glucose-based analogues of phosphatidylinositol 3-phosphate were straightforwardly synthesised from 2,3,4,6-tetra-O-acetyl-D-glucosyl bromide as protein kinase B (PKB/Akt) inhibitors. β-D-Glucuronyl diethyl phosphoramidate was identified as a promising hit through biological screening in two different cellular systems. In addition, RNA interference experiments (siRNA) provide evidence of the ability of the compound to exert biological effects specifically through Akt signalling.

Original languageEnglish
Pages (from-to)1291-1298
Number of pages8
JournalCarbohydrate Research
Issue number10
Publication statusPublished - Jul 2 2010


  • Analogues
  • Cyclitol analogues
  • Enzyme inhibitors
  • Glucose
  • Glycolipid
  • PKB
  • Sugar phosphoramidates

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Organic Chemistry
  • Medicine(all)


Dive into the research topics of 'Straightforward synthesis of novel Akt inhibitors based on a glucose scaffold'. Together they form a unique fingerprint.

Cite this