Stimulation of the globus pallidus internus for childhood-onset dystonia

Giovanna Zorzi, Carlo Marras, Nardo Nardocci, Angelo Franzini, Luisa Chiapparini, Elio Maccagnano, Lucia Angelini, Dario Caldiroli, Giovanni Broggi

Research output: Contribution to journalArticlepeer-review


We report the results of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in 12 patients with childhood-onset generalized dystonia refractory to medication, including 3 patients with status dystonicus. There were 8 patients who had DYT1-negative primary dystonia, 1 had DYT1-positive dystonia, and 3 had symptomatic dystonia. Stimulation was effective in all but 1 patient. Dystonic postures and movements of the axis and limbs responded to DBS to a greater extent than oromandibular dystonia and fixed dystonic postures. These findings provide further evidence that pallidal stimulation is an effective treatment for intractable childhood-onset dystonia, including status dystonicus, and together with previous findings, suggest that it should be considered the treatment of choice for these conditions.

Original languageEnglish
Pages (from-to)1194-1200
Number of pages7
JournalMovement Disorders
Issue number9
Publication statusPublished - Sept 2005


  • Childhood dystonia
  • Globus pallidus
  • Status dystonicus
  • Stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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