Stephen Paget and the 'seed and soil' theory of metastatic dissemination

D. Ribatti; G. Mangialardi; A. Vacca

doi:10.1007/s10238-006-0117-4

Stephen Paget and the 'seed and soil' theory of metastatic dissemination

D. Ribatti, G. Mangialardi, A. Vacca

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Article › peer-review

Abstract

The outcome of cancer metastasis depends on multiple interactions between selected metastatic cells and homeostatic mechanisms unique to some organ microenvironments. The English surgeon Stephen Paget (1855-1926) is credited with being the first to postulate the important role played by microenvironment in metastasis formation. The concept of his 'seed and soil' theory has been supported and confirmed by numerous publications. This review article summarises the most important literature data about this matter.

Original language	English
Pages (from-to)	145-149
Number of pages	5
Journal	Clinical and Experimental Medicine
Volume	6
Issue number	4
DOIs	https://doi.org/10.1007/s10238-006-0117-4
Publication status	Published - Dec 2006

Keywords

History of medicine
Metastasis
Tumour growth

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)
Clinical Biochemistry

Access to Document

10.1007/s10238-006-0117-4

Cite this

@article{a5eaccc894ea44a3ad359b1896645a2e,

title = "Stephen Paget and the 'seed and soil' theory of metastatic dissemination",

abstract = "The outcome of cancer metastasis depends on multiple interactions between selected metastatic cells and homeostatic mechanisms unique to some organ microenvironments. The English surgeon Stephen Paget (1855-1926) is credited with being the first to postulate the important role played by microenvironment in metastasis formation. The concept of his 'seed and soil' theory has been supported and confirmed by numerous publications. This review article summarises the most important literature data about this matter.",

keywords = "History of medicine, Metastasis, Tumour growth",

author = "D. Ribatti and G. Mangialardi and A. Vacca",

year = "2006",

month = dec,

doi = "10.1007/s10238-006-0117-4",

language = "English",

volume = "6",

pages = "145--149",

journal = "Zeitschrift f{\"u}r Die Gesamte Experimentelle Medizin",

issn = "1591-8890",

publisher = "Springer-Verlag Italia",

number = "4",

}

TY - JOUR

T1 - Stephen Paget and the 'seed and soil' theory of metastatic dissemination

AU - Ribatti, D.

AU - Mangialardi, G.

AU - Vacca, A.

PY - 2006/12

Y1 - 2006/12

N2 - The outcome of cancer metastasis depends on multiple interactions between selected metastatic cells and homeostatic mechanisms unique to some organ microenvironments. The English surgeon Stephen Paget (1855-1926) is credited with being the first to postulate the important role played by microenvironment in metastasis formation. The concept of his 'seed and soil' theory has been supported and confirmed by numerous publications. This review article summarises the most important literature data about this matter.

AB - The outcome of cancer metastasis depends on multiple interactions between selected metastatic cells and homeostatic mechanisms unique to some organ microenvironments. The English surgeon Stephen Paget (1855-1926) is credited with being the first to postulate the important role played by microenvironment in metastasis formation. The concept of his 'seed and soil' theory has been supported and confirmed by numerous publications. This review article summarises the most important literature data about this matter.

KW - History of medicine

KW - Metastasis

KW - Tumour growth

UR - http://www.scopus.com/inward/record.url?scp=33845881985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845881985&partnerID=8YFLogxK

U2 - 10.1007/s10238-006-0117-4

DO - 10.1007/s10238-006-0117-4

M3 - Article

C2 - 17191105

AN - SCOPUS:33845881985

SN - 1591-8890

VL - 6

SP - 145

EP - 149

JO - Zeitschrift für Die Gesamte Experimentelle Medizin

JF - Zeitschrift für Die Gesamte Experimentelle Medizin

IS - 4

ER -

Stephen Paget and the 'seed and soil' theory of metastatic dissemination

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this