Statins and autoimmune diseases

Victor S. Gurevich; Ora Shovman; Liat Slutzky; Pier Luigi Meroni; Yehuda Shoenfeld

doi:10.1016/j.autrev.2004.08.037

Statins and autoimmune diseases

Victor S. Gurevich, Ora Shovman, Liat Slutzky, Pier Luigi Meroni, Yehuda Shoenfeld

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugs widely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system.

Original language	English
Pages (from-to)	123-129
Number of pages	7
Journal	Autoimmunity Reviews
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.autrev.2004.08.037
Publication status	Published - Mar 2005

Keywords

Anti-inflammatory
Anti-phospholipid syndrome
Atherosclerosis
Immunomodulatory
Inflammatory arthritis
Neuroinflammatory diseases
SLE
Statins

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.1016/j.autrev.2004.08.037

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title = "Statins and autoimmune diseases",

abstract = "Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugs widely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system.",

keywords = "Anti-inflammatory, Anti-phospholipid syndrome, Atherosclerosis, Immunomodulatory, Inflammatory arthritis, Neuroinflammatory diseases, SLE, Statins",

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AU - Meroni, Pier Luigi

AU - Shoenfeld, Yehuda

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AB - Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugs widely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system.

KW - Anti-inflammatory

KW - Anti-phospholipid syndrome

KW - Atherosclerosis

KW - Immunomodulatory

KW - Inflammatory arthritis

KW - Neuroinflammatory diseases

KW - SLE

KW - Statins

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Statins and autoimmune diseases

Abstract

Keywords

ASJC Scopus subject areas

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