STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway

Maria Anele Romeo, Maria Saveria Gilardini Montani, Rossella Benedetti, Roberta Santarelli, Gabriella D'Orazi, Mara Cirone

Research output: Contribution to journalArticlepeer-review


Oncosuppressor TP53 and oncogene STAT3 have been shown to engage an interplay in which they negatively influence each other. Conversely, mutant (mut) p53 may sustain STAT3 phosphorylation by displacing SH2 phosphatase while whether STAT3 could influence mutp53 has not been clarified yet. In this study we found that pharmacologic or genetic inhibition of STAT3 in both glioblastoma and pancreatic cancer cells, carrying mutp53 protein, reduced mutp53 expression level by down-regulating chaperone HSP90 as well as molecules belonging to the mevalonate pathway. On the other hand, HSP90 and the mevalonate pathway were involved in sustaining STAT3 phosphorylation mediated by mutp53. In conclusion, this study unveils for the first time that mutp53 can establish with STAT3, similarly to what observed with other oncogenic pathways, a criminal alliance with a crucial role in promoting cancerogenesis.

Original languageEnglish
Article number1102
JournalFrontiers in Oncology
Publication statusPublished - Jul 10 2020


  • glioblastoma
  • HSP90
  • mevalonate kinase
  • mutp53
  • pancreatic cancer
  • STAT3

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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