Staphylococcus lugdunensis, an aggressive coagulase-negative pathogen not to be underestimated

Stefano Ravaioli; Laura Selan; Livia Visai; Valter Pirini; Davide Campoccia; Alessandra Maso; Pietro Speziale; Lucio Montanaro; Carla Renata Arciola

doi:10.5301/ijao.5000142

Staphylococcus lugdunensis, an aggressive coagulase-negative pathogen not to be underestimated

Stefano Ravaioli, Laura Selan, Livia Visai, Valter Pirini, Davide Campoccia, Alessandra Maso, Pietro Speziale, Lucio Montanaro, Carla Renata Arciola

Research output: Contribution to journal › Article › peer-review

Abstract

The new emerging coagulase-negative pathogen Staphylococcus lugdunensis is responsible for severe cardiac and joint infections. Since the biochemical phenotypic systems designed for the identification of CoNS do not appear to be species specific and are hardly reliable for the discrimination of S. lugdunensis from other staphylococci, its precise identification requires fine molecular methods. The pathogenic mechanisms by which S. lugdunensis causes severe infections are not yet completely elucidated and in this review its virulence and toxic determinants are surveyed as well as its adhesions and biofilm production.

Original language	English
Pages (from-to)	742-753
Number of pages	12
Journal	International Journal of Artificial Organs
Volume	35
Issue number	10
DOIs	https://doi.org/10.5301/ijao.5000142
Publication status	Published - 2012

Keywords

Adhesins
Agr-like system
AtlL
Biofilm
Coagulase negative staphylococci
ICA locus
Iron-regulated surface determinant system
SLUSH locus
Staphylococcus lugdunensis

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Bioengineering
Medicine (miscellaneous)

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10.5301/ijao.5000142

Cite this

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title = "Staphylococcus lugdunensis, an aggressive coagulase-negative pathogen not to be underestimated",

abstract = "The new emerging coagulase-negative pathogen Staphylococcus lugdunensis is responsible for severe cardiac and joint infections. Since the biochemical phenotypic systems designed for the identification of CoNS do not appear to be species specific and are hardly reliable for the discrimination of S. lugdunensis from other staphylococci, its precise identification requires fine molecular methods. The pathogenic mechanisms by which S. lugdunensis causes severe infections are not yet completely elucidated and in this review its virulence and toxic determinants are surveyed as well as its adhesions and biofilm production.",

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AU - Ravaioli, Stefano

AU - Selan, Laura

AU - Visai, Livia

AU - Pirini, Valter

AU - Campoccia, Davide

AU - Maso, Alessandra

AU - Speziale, Pietro

AU - Montanaro, Lucio

AU - Arciola, Carla Renata

PY - 2012

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AB - The new emerging coagulase-negative pathogen Staphylococcus lugdunensis is responsible for severe cardiac and joint infections. Since the biochemical phenotypic systems designed for the identification of CoNS do not appear to be species specific and are hardly reliable for the discrimination of S. lugdunensis from other staphylococci, its precise identification requires fine molecular methods. The pathogenic mechanisms by which S. lugdunensis causes severe infections are not yet completely elucidated and in this review its virulence and toxic determinants are surveyed as well as its adhesions and biofilm production.

KW - Adhesins

KW - Agr-like system

KW - AtlL

KW - Biofilm

KW - Coagulase negative staphylococci

KW - ICA locus

KW - Iron-regulated surface determinant system

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Staphylococcus lugdunensis, an aggressive coagulase-negative pathogen not to be underestimated

Abstract

Keywords

ASJC Scopus subject areas

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