Staphylococcus lugdunensis, an aggressive coagulase-negative pathogen not to be underestimated

Stefano Ravaioli, Laura Selan, Livia Visai, Valter Pirini, Davide Campoccia, Alessandra Maso, Pietro Speziale, Lucio Montanaro, Carla Renata Arciola

Research output: Contribution to journalArticlepeer-review


The new emerging coagulase-negative pathogen Staphylococcus lugdunensis is responsible for severe cardiac and joint infections. Since the biochemical phenotypic systems designed for the identification of CoNS do not appear to be species specific and are hardly reliable for the discrimination of S. lugdunensis from other staphylococci, its precise identification requires fine molecular methods. The pathogenic mechanisms by which S. lugdunensis causes severe infections are not yet completely elucidated and in this review its virulence and toxic determinants are surveyed as well as its adhesions and biofilm production.

Original languageEnglish
Pages (from-to)742-753
Number of pages12
JournalInternational Journal of Artificial Organs
Issue number10
Publication statusPublished - 2012


  • Adhesins
  • Agr-like system
  • AtlL
  • Biofilm
  • Coagulase negative staphylococci
  • ICA locus
  • Iron-regulated surface determinant system
  • SLUSH locus
  • Staphylococcus lugdunensis

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)


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