Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: The CDH EURO Consortium Consensus - 2015 Update

Kitty G. Snoek; Irwin K M Reiss; Anne Greenough; Irma Capolupo; Berndt Urlesberger; Lucas Wessel; Laurent Storme; Jan Deprest; Thomas Schaible; Arno Van Heijst; Dick Tibboel; K. Allegaert; A. Debeer; R. Keijzer; A. Benachi; P. Tissieres; F. Kipfmueller; T. Schaible; C. Breatnach; N. Patel; E. Leva; F. Ciralli; P. Bagolan; A. Dotta; F. Morini; A. Di Pede; R. Emblem; K. Ertesvag; M. Migdal; A. Piotrowski; B. Frenckner; C. Mesas; D. Elorza; L. Martinez; H. Scharbatke; T. Cohen-Overbeek; A. J. Eggink; U. S. Kraemer; D. Tibboel; R. M H Wijnen; J. Deprest; P. De Coppi; S. Eaton; M. Davenport

doi:10.1159/000444210

Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: The CDH EURO Consortium Consensus - 2015 Update

Kitty G. Snoek, Irwin K M Reiss, Anne Greenough, Irma Capolupo, Berndt Urlesberger, Lucas Wessel, Laurent Storme, Jan Deprest, Thomas Schaible, Arno Van Heijst, Dick Tibboel, K. Allegaert, A. Debeer, R. Keijzer, A. Benachi, P. Tissieres, F. Kipfmueller, T. Schaible, C. Breatnach, N. PatelE. Leva, F. Ciralli, P. Bagolan, A. Dotta, F. Morini, A. Di Pede, R. Emblem, K. Ertesvag, M. Migdal, A. Piotrowski, B. Frenckner, C. Mesas, D. Elorza, L. Martinez, H. Scharbatke, T. Cohen-Overbeek, A. J. Eggink, U. S. Kraemer, D. Tibboel, R. M H Wijnen, J. Deprest, P. De Coppi, S. Eaton, M. Davenport

Research output: Contribution to journal › Article › peer-review

Abstract

In 2010, the congenital diaphragmatic hernia (CDH) EURO Consortium published a standardized neonatal treatment protocol. Five years later, the number of participating centers has been raised from 13 to 22. In this article the relevant literature is updated, and consensus has been reached between the members of the CDH EURO Consortium. Key updated recommendations are: (1) planned delivery after a gestational age of 39 weeks in a high-volume tertiary center; (2) neuromuscular blocking agents to be avoided during initial treatment in the delivery room; (3) adapt treatment to reach a preductal saturation of between 80 and 95% and postductal saturation >70%; (4) target PaCO₂ to be between 50 and 70 mm Hg; (5) conventional mechanical ventilation to be the optimal initial ventilation strategy, and (6) intravenous sildenafil to be considered in CDH patients with severe pulmonary hypertension. This article represents the current opinion of all consortium members in Europe for the optimal neonatal treatment of CDH.

Original language	English
Pages (from-to)	66-74
Number of pages	9
Journal	Neonatology
Volume	110
Issue number	1
DOIs	https://doi.org/10.1159/000444210
Publication status	Published - Jun 1 2016

Keywords

Congenital diaphragmatic hernia
Consensus
Standardized treatment

ASJC Scopus subject areas

Developmental Biology
Pediatrics, Perinatology, and Child Health

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10.1159/000444210

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Snoek, K. G., Reiss, I. K. M., Greenough, A., Capolupo, I., Urlesberger, B., Wessel, L., Storme, L., Deprest, J., Schaible, T., Van Heijst, A., Tibboel, D., Allegaert, K., Debeer, A., Keijzer, R., Benachi, A., Tissieres, P., Kipfmueller, F., Schaible, T., Breatnach, C., ... Davenport, M. (2016). Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: The CDH EURO Consortium Consensus - 2015 Update. Neonatology, 110(1), 66-74. https://doi.org/10.1159/000444210

Snoek, KG, Reiss, IKM, Greenough, A, Capolupo, I, Urlesberger, B, Wessel, L, Storme, L, Deprest, J, Schaible, T, Van Heijst, A, Tibboel, D, Allegaert, K, Debeer, A, Keijzer, R, Benachi, A, Tissieres, P, Kipfmueller, F, Schaible, T, Breatnach, C, Patel, N, Leva, E, Ciralli, F, Bagolan, P , Dotta, A, Morini, F, Di Pede, A, Emblem, R, Ertesvag, K, Migdal, M, Piotrowski, A, Frenckner, B, Mesas, C, Elorza, D, Martinez, L, Scharbatke, H, Cohen-Overbeek, T, Eggink, AJ, Kraemer, US, Tibboel, D, Wijnen, RMH, Deprest, J, De Coppi, P, Eaton, S & Davenport, M 2016, 'Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: The CDH EURO Consortium Consensus - 2015 Update', Neonatology, vol. 110, no. 1, pp. 66-74. https://doi.org/10.1159/000444210

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title = "Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: The CDH EURO Consortium Consensus - 2015 Update",

abstract = "In 2010, the congenital diaphragmatic hernia (CDH) EURO Consortium published a standardized neonatal treatment protocol. Five years later, the number of participating centers has been raised from 13 to 22. In this article the relevant literature is updated, and consensus has been reached between the members of the CDH EURO Consortium. Key updated recommendations are: (1) planned delivery after a gestational age of 39 weeks in a high-volume tertiary center; (2) neuromuscular blocking agents to be avoided during initial treatment in the delivery room; (3) adapt treatment to reach a preductal saturation of between 80 and 95% and postductal saturation >70%; (4) target PaCO2 to be between 50 and 70 mm Hg; (5) conventional mechanical ventilation to be the optimal initial ventilation strategy, and (6) intravenous sildenafil to be considered in CDH patients with severe pulmonary hypertension. This article represents the current opinion of all consortium members in Europe for the optimal neonatal treatment of CDH.",

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AU - Snoek, Kitty G.

AU - Reiss, Irwin K M

AU - Greenough, Anne

AU - Capolupo, Irma

AU - Urlesberger, Berndt

AU - Wessel, Lucas

AU - Storme, Laurent

AU - Deprest, Jan

AU - Schaible, Thomas

AU - Van Heijst, Arno

AU - Tibboel, Dick

AU - Allegaert, K.

AU - Debeer, A.

AU - Keijzer, R.

AU - Benachi, A.

AU - Tissieres, P.

AU - Kipfmueller, F.

AU - Schaible, T.

AU - Breatnach, C.

AU - Patel, N.

AU - Leva, E.

AU - Ciralli, F.

AU - Bagolan, P.

AU - Dotta, A.

AU - Morini, F.

AU - Di Pede, A.

AU - Emblem, R.

AU - Ertesvag, K.

AU - Migdal, M.

AU - Piotrowski, A.

AU - Frenckner, B.

AU - Mesas, C.

AU - Elorza, D.

AU - Martinez, L.

AU - Scharbatke, H.

AU - Cohen-Overbeek, T.

AU - Eggink, A. J.

AU - Kraemer, U. S.

AU - Tibboel, D.

AU - Wijnen, R. M H

AU - Deprest, J.

AU - De Coppi, P.

AU - Eaton, S.

AU - Davenport, M.

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Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: The CDH EURO Consortium Consensus - 2015 Update

Abstract

Keywords

ASJC Scopus subject areas

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