Spontaneous transformation of human fibroblast cultures derived from bronchial carcinomata

Bruno Azzarone; Delfina Pedullà

doi:10.1016/0014-2964(76)90162-6

Spontaneous transformation of human fibroblast cultures derived from bronchial carcinomata

Bruno Azzarone, Delfina Pedullà

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Stromal fibroblasts derived from human tumours have been always considered normal cells. In this report it is shown that fibroblasts derived from lung cancers, regularly under go spontaneous transformation when cultured in crowded growth conditions, while fibroblasts derived from non-neoplastic tissues do not transform. This particular behaviour may reflect a preneoplastic state of stromal fibroblasts derived from lung cancers.

Original language	English
Pages (from-to)	557-561
Number of pages	5
Journal	European Journal of Cancer (1965)
Volume	12
Issue number	7
DOIs	https://doi.org/10.1016/0014-2964(76)90162-6
Publication status	Published - 1976

ASJC Scopus subject areas

Oncology

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10.1016/0014-2964(76)90162-6

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title = "Spontaneous transformation of human fibroblast cultures derived from bronchial carcinomata",

abstract = "Stromal fibroblasts derived from human tumours have been always considered normal cells. In this report it is shown that fibroblasts derived from lung cancers, regularly under go spontaneous transformation when cultured in crowded growth conditions, while fibroblasts derived from non-neoplastic tissues do not transform. This particular behaviour may reflect a preneoplastic state of stromal fibroblasts derived from lung cancers.",

author = "Bruno Azzarone and Delfina Pedull{\`a}",

year = "1976",

doi = "10.1016/0014-2964(76)90162-6",

language = "English",

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journal = "European Journal of Cancer",

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AU - Azzarone, Bruno

AU - Pedullà, Delfina

PY - 1976

Y1 - 1976

N2 - Stromal fibroblasts derived from human tumours have been always considered normal cells. In this report it is shown that fibroblasts derived from lung cancers, regularly under go spontaneous transformation when cultured in crowded growth conditions, while fibroblasts derived from non-neoplastic tissues do not transform. This particular behaviour may reflect a preneoplastic state of stromal fibroblasts derived from lung cancers.

AB - Stromal fibroblasts derived from human tumours have been always considered normal cells. In this report it is shown that fibroblasts derived from lung cancers, regularly under go spontaneous transformation when cultured in crowded growth conditions, while fibroblasts derived from non-neoplastic tissues do not transform. This particular behaviour may reflect a preneoplastic state of stromal fibroblasts derived from lung cancers.

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M3 - Article

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JO - European Journal of Cancer

JF - European Journal of Cancer

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ER -

Spontaneous transformation of human fibroblast cultures derived from bronchial carcinomata

Abstract

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