Splenic irradiation before bone marrow transplantation for chronic myeloid leukemia: Update of a prospective randomized study

A. Gratwohl; J. Hermans; A. V. Biezen; W. Arcese; T. De Witte; L. Debusscher; P. Ernst; A. Ferrant; F. Frassoni; G. Gahrton; A. Iriondo; H. J. Kolb; H. Link; D. Niederwieser; T. Ruutu; N. Schmitz; W. Siegert; A. Torres-Gomez; J. P. Vernant; F. E. Zwaan

doi:10.3109/10428199309047891

Splenic irradiation before bone marrow transplantation for chronic myeloid leukemia: Update of a prospective randomized study

A. Gratwohl, J. Hermans, A. V. Biezen, W. Arcese, T. De Witte, L. Debusscher, P. Ernst, A. Ferrant, F. Frassoni, G. Gahrton, A. Iriondo, H. J. Kolb, H. Link, D. Niederwieser, T. Ruutu, N. Schmitz, W. Siegert, A. Torres-Gomez, J. P. Vernant, F. E. Zwaan

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Two hundred and twenty-nine patients with chronic myeloid leukaemia in chronic phase awaiting bone marrow transplantation from an HLA-identical sibling donor were randomized as part of their conditioning, to receive splenic irradiation (SI+ 115 patients), or not (SI-, 114 patients). Both groups were identical in regard to age, sex, donor/recipient sex combination and disease activity. Survival, leukaemia-free survival, incidence of transplant-related mortality, acute and chronic graft versus host disease, incidence of rejection and probability of relapse were not different in either groups at a median follow-up time of 4.5 years (minimum follow-up 2 years). Recovery of peripheral white blood cell counts to 1 × 10⁹/1 but not of platelet counts to 50 × 10⁹/1 was significantly faster in patients with SI+ (21 vs 24 days). This small benefit does not justify routine splenic irradiation prior to BMT, in CML.

Original language	English
Pages (from-to)	227-231
Number of pages	5
Journal	Leukemia and Lymphoma
Volume	11
Issue number	s1
DOIs	https://doi.org/10.3109/10428199309047891
Publication status	Published - 1993

Keywords

BMT
CML
Splenic irradiation

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.3109/10428199309047891

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Gratwohl, A., Hermans, J., Biezen, A. V., Arcese, W., Witte, T. D., Debusscher, L., Ernst, P., Ferrant, A., Frassoni, F., Gahrton, G., Iriondo, A., Kolb, H. J., Link, H., Niederwieser, D., Ruutu, T., Schmitz, N., Siegert, W., Torres-Gomez, A., Vernant, J. P., & Zwaan, F. E. (1993). Splenic irradiation before bone marrow transplantation for chronic myeloid leukemia: Update of a prospective randomized study. Leukemia and Lymphoma, 11(s1), 227-231. https://doi.org/10.3109/10428199309047891

Gratwohl, A, Hermans, J, Biezen, AV, Arcese, W, Witte, TD, Debusscher, L, Ernst, P, Ferrant, A, Frassoni, F, Gahrton, G, Iriondo, A, Kolb, HJ, Link, H, Niederwieser, D, Ruutu, T, Schmitz, N, Siegert, W, Torres-Gomez, A, Vernant, JP & Zwaan, FE 1993, 'Splenic irradiation before bone marrow transplantation for chronic myeloid leukemia: Update of a prospective randomized study', Leukemia and Lymphoma, vol. 11, no. s1, pp. 227-231. https://doi.org/10.3109/10428199309047891

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abstract = "Two hundred and twenty-nine patients with chronic myeloid leukaemia in chronic phase awaiting bone marrow transplantation from an HLA-identical sibling donor were randomized as part of their conditioning, to receive splenic irradiation (SI+ 115 patients), or not (SI-, 114 patients). Both groups were identical in regard to age, sex, donor/recipient sex combination and disease activity. Survival, leukaemia-free survival, incidence of transplant-related mortality, acute and chronic graft versus host disease, incidence of rejection and probability of relapse were not different in either groups at a median follow-up time of 4.5 years (minimum follow-up 2 years). Recovery of peripheral white blood cell counts to 1 × 109/1 but not of platelet counts to 50 × 109/1 was significantly faster in patients with SI+ (21 vs 24 days). This small benefit does not justify routine splenic irradiation prior to BMT, in CML.",

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AU - Gratwohl, A.

AU - Hermans, J.

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AU - Arcese, W.

AU - Witte, T. De

AU - Debusscher, L.

AU - Ernst, P.

AU - Ferrant, A.

AU - Frassoni, F.

AU - Gahrton, G.

AU - Iriondo, A.

AU - Kolb, H. J.

AU - Link, H.

AU - Niederwieser, D.

AU - Ruutu, T.

AU - Schmitz, N.

AU - Siegert, W.

AU - Torres-Gomez, A.

AU - Vernant, J. P.

AU - Zwaan, F. E.

PY - 1993

Y1 - 1993

N2 - Two hundred and twenty-nine patients with chronic myeloid leukaemia in chronic phase awaiting bone marrow transplantation from an HLA-identical sibling donor were randomized as part of their conditioning, to receive splenic irradiation (SI+ 115 patients), or not (SI-, 114 patients). Both groups were identical in regard to age, sex, donor/recipient sex combination and disease activity. Survival, leukaemia-free survival, incidence of transplant-related mortality, acute and chronic graft versus host disease, incidence of rejection and probability of relapse were not different in either groups at a median follow-up time of 4.5 years (minimum follow-up 2 years). Recovery of peripheral white blood cell counts to 1 × 109/1 but not of platelet counts to 50 × 109/1 was significantly faster in patients with SI+ (21 vs 24 days). This small benefit does not justify routine splenic irradiation prior to BMT, in CML.

AB - Two hundred and twenty-nine patients with chronic myeloid leukaemia in chronic phase awaiting bone marrow transplantation from an HLA-identical sibling donor were randomized as part of their conditioning, to receive splenic irradiation (SI+ 115 patients), or not (SI-, 114 patients). Both groups were identical in regard to age, sex, donor/recipient sex combination and disease activity. Survival, leukaemia-free survival, incidence of transplant-related mortality, acute and chronic graft versus host disease, incidence of rejection and probability of relapse were not different in either groups at a median follow-up time of 4.5 years (minimum follow-up 2 years). Recovery of peripheral white blood cell counts to 1 × 109/1 but not of platelet counts to 50 × 109/1 was significantly faster in patients with SI+ (21 vs 24 days). This small benefit does not justify routine splenic irradiation prior to BMT, in CML.

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Splenic irradiation before bone marrow transplantation for chronic myeloid leukemia: Update of a prospective randomized study

Abstract

Keywords

ASJC Scopus subject areas

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