TY - JOUR
T1 - Spironolactone improves lung diffussion in chronic heart failure
AU - Agostoni, Piergiuseppe
AU - Magini, Alessandra
AU - Andreini, Daniele
AU - Contini, Mauro
AU - Apostolo, Anna
AU - Bussotti, Maurizio
AU - Cattadori, Gaia
AU - Palermo, Pietro
PY - 2005/1
Y1 - 2005/1
N2 - Aims: To evaluate whether anti-aldosteronic treatment influences lung diffusion (DLco) in chronic heart failure (HF) patients. Spironolactone improves clinical conditions and prognosis in chronic HF and reduces connective tissue matrix turnover; DLco abnormalities in chronic HF are related to increase in fibrosis and connective tissue derangement. Methods and results: Thirty stable chronic HF patients, with reduced DLco (2 16.8 ± 1.9 vs. 18.6 ± 2.2 mL/min/kg). Increments of DLco and peak VO2 were linearly related (R = 0.849, P <0.001). Conclusion: These data show a positive effect of spironolactone on gas diffusion and exercise capacity suggesting a novel mechanism by which anti-aldosteronic drugs improve HF clinical condition and prognosis.
AB - Aims: To evaluate whether anti-aldosteronic treatment influences lung diffusion (DLco) in chronic heart failure (HF) patients. Spironolactone improves clinical conditions and prognosis in chronic HF and reduces connective tissue matrix turnover; DLco abnormalities in chronic HF are related to increase in fibrosis and connective tissue derangement. Methods and results: Thirty stable chronic HF patients, with reduced DLco (2 16.8 ± 1.9 vs. 18.6 ± 2.2 mL/min/kg). Increments of DLco and peak VO2 were linearly related (R = 0.849, P <0.001). Conclusion: These data show a positive effect of spironolactone on gas diffusion and exercise capacity suggesting a novel mechanism by which anti-aldosteronic drugs improve HF clinical condition and prognosis.
KW - Anti-aldosteronic drugs
KW - Exercise
KW - Heart failure
KW - Lung diffusion capacity
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U2 - 10.1093/eurheartj/ehi023
DO - 10.1093/eurheartj/ehi023
M3 - Article
C2 - 15618072
AN - SCOPUS:14144254868
SN - 0195-668X
VL - 26
SP - 159
EP - 164
JO - European Heart Journal
JF - European Heart Journal
IS - 2
ER -