Spine-Ghost: A new bioactive cement for vertebroplasty

Chiara Vitale-Brovarone, Lucia Pontiroli, Giorgia Novajra, Ion Tcacencu, Joana Reis, Antonio Manca

Research output: Chapter in Book/Report/Conference proceedingConference contribution


An innovative, resorbable and injectable composite cement (Spine-Ghost) to be used for augmentation and restoration of fractured vertebrae was developed. Type III α-calcium sulfate hemihydrate (CSH) was selected as the bioresorbable matrix, while spray-dried mesoporous bioactive particles (SD-MBP, composition 80/20% mol SiC2/CaO), were added to impart high bioactive properties to the cement; a glass-ceramic containing zirconia was chosen as a second dispersed phase, in order to increase the radiopacity of the material. After mixing with water, an injectable paste was obtained. The developed cement proved to be mechanically compatible with healthy cancellous bone, resorbable and bioactive by soaking in simulated body fluid (SBF), cytocompatible through in-vitro cell cultures and it could be injected in ex-vivo sheep vertebra. Comparisons with a commercial control were carried out.

Original languageEnglish
Title of host publicationBioceramics 26
PublisherTrans Tech Publications Ltd
Number of pages5
ISBN (Print)9783038352822
Publication statusPublished - 2015
Event26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2014 - Barcelona, Spain
Duration: Nov 6 2014Nov 8 2014

Publication series

NameKey Engineering Materials
ISSN (Print)10139826


Other26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2014


  • Bioresorbable cement
  • Mesoporous bioactive glass
  • Spray-drying
  • Vertebroplasty

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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