TY - GEN
T1 - Spine-Ghost
T2 - 26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2014
AU - Vitale-Brovarone, Chiara
AU - Pontiroli, Lucia
AU - Novajra, Giorgia
AU - Tcacencu, Ion
AU - Reis, Joana
AU - Manca, Antonio
PY - 2015
Y1 - 2015
N2 - An innovative, resorbable and injectable composite cement (Spine-Ghost) to be used for augmentation and restoration of fractured vertebrae was developed. Type III α-calcium sulfate hemihydrate (CSH) was selected as the bioresorbable matrix, while spray-dried mesoporous bioactive particles (SD-MBP, composition 80/20% mol SiC2/CaO), were added to impart high bioactive properties to the cement; a glass-ceramic containing zirconia was chosen as a second dispersed phase, in order to increase the radiopacity of the material. After mixing with water, an injectable paste was obtained. The developed cement proved to be mechanically compatible with healthy cancellous bone, resorbable and bioactive by soaking in simulated body fluid (SBF), cytocompatible through in-vitro cell cultures and it could be injected in ex-vivo sheep vertebra. Comparisons with a commercial control were carried out.
AB - An innovative, resorbable and injectable composite cement (Spine-Ghost) to be used for augmentation and restoration of fractured vertebrae was developed. Type III α-calcium sulfate hemihydrate (CSH) was selected as the bioresorbable matrix, while spray-dried mesoporous bioactive particles (SD-MBP, composition 80/20% mol SiC2/CaO), were added to impart high bioactive properties to the cement; a glass-ceramic containing zirconia was chosen as a second dispersed phase, in order to increase the radiopacity of the material. After mixing with water, an injectable paste was obtained. The developed cement proved to be mechanically compatible with healthy cancellous bone, resorbable and bioactive by soaking in simulated body fluid (SBF), cytocompatible through in-vitro cell cultures and it could be injected in ex-vivo sheep vertebra. Comparisons with a commercial control were carried out.
KW - Bioresorbable cement
KW - Mesoporous bioactive glass
KW - Spray-drying
KW - Vertebroplasty
UR - http://www.scopus.com/inward/record.url?scp=84921709791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84921709791&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net.KEM.631.43
DO - 10.4028/www.scientific.net.KEM.631.43
M3 - Conference contribution
AN - SCOPUS:84921709791
SN - 9783038352822
VL - 631
T3 - Key Engineering Materials
SP - 43
EP - 47
BT - Bioceramics 26
PB - Trans Tech Publications Ltd
Y2 - 6 November 2014 through 8 November 2014
ER -