Abstract
Diazepam showed an antimetrazol activity which was longer-lasting in mice than in rats. The levels of diazepam in blood and brain were similar in both species but N-desmethyl metabolites ofdiazepam accumulated in mouse brain while they were practically undetectable in rat brain. The three main metabolites of diazepam, namely N-methyloxazepam, N-desmethyldiazepam and oxazepam showed strong anticonvulsant activity in mice.
| Original language | English |
|---|---|
| Pages (from-to) | 467-470 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 4 |
| Issue number | 4 |
| Publication status | Published - Nov 1968 |
Keywords
- Anticonvulsant activity
- Diazepam
- Diazepam blood level
- Diazepam brain level
- Metrazol
- N-desmethyldiazepam
- N-Methyloxazepam
- Oxazepam
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology