Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: Initial application to the GENFI cohort

The Genetic Frontotemporal Dementia Initiative (GENFI)

Research output: Contribution to journalArticlepeer-review


Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used to track neurodegenerative disease progression. In diseases such as frontotemporal dementia or Alzheimer's disease, atrophy can be observed in key brain structures years before any clinical symptoms are present. Atrophy is most commonly captured as volume change of key structures and the shape changes of these structures are typically not analysed despite being potentially more sensitive than summary volume statistics over the entire structure. In this paper we propose a spatiotemporal analysis pipeline based on Large Diffeomorphic Deformation Metric Mapping (LDDMM) to detect shape changes from volumetric MRI scans. We applied our framework to a cohort of individuals with genetic variants of frontotemporal dementia and healthy controls from the Genetic FTD Initiative (GENFI) study. Our method, take full advantage of the LDDMM framework, and relies on the creation of a population specific average spatiotemporal trajectory of a relevant brain structure of interest, the thalamus in our case. The residuals from each patient data to the average spatiotemporal trajectory are then clustered and studied to assess when presymptomatic mutation carriers differ from healthy control subjects. We found statistical differences in shape in the anterior region of the thalamus at least five years before the mutation carrier subjects develop any clinical symptoms. This region of the thalamus has been shown to be predominantly connected to the frontal lobe, consistent with the pattern of cortical atrophy seen in the disease.

Original languageEnglish
Pages (from-to)282-290
Number of pages9
Publication statusPublished - 2019


  • Clustering
  • Computational anatomy
  • Parallel transport
  • Shape analysis
  • Spatiotemporal geodesic regression
  • Thalamus
  • adult
  • Article
  • brain atrophy
  • brain size
  • controlled study
  • degenerative disease
  • female
  • frontal lobe
  • frontotemporal dementia
  • gene mutation
  • genetic variability
  • human
  • major clinical study
  • male
  • nuclear magnetic resonance imaging
  • priority journal
  • spatiotemporal analysis
  • thalamus


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