Somatostatin as a Regulator of First-Trimester Human Trophoblast Functions

C. Biondi; M. E. Ferretti; L. Lunghi; S. Medici; F. Cervellati; L. Abelli; F. Bertoni; E. Adinolfi; F. Vesce; G. Bartolini; A. Papi; S. D'Andrea; S. Berton; G. Baldassarre

doi:10.1016/j.placenta.2008.05.009

Somatostatin as a Regulator of First-Trimester Human Trophoblast Functions

C. Biondi, M. E. Ferretti, L. Lunghi, S. Medici, F. Cervellati, L. Abelli, F. Bertoni, E. Adinolfi, F. Vesce, G. Bartolini, A. Papi, S. D'Andrea, S. Berton, G. Baldassarre

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

We have tested the hypothesis that human early trophoblast is a target for somatostatin (SRIF) regulatory actions. We report for the first time that SSTR2A and 2B transcripts and proteins are present in first-trimester human chorionic villi and the trophoblast-derived HTR-8/SVneo and JAR cells. In both cell lines, SSTR are functional since SRIF inhibits cyclic AMP pathway, stimulates arachidonic acid release and enhances cell proliferation. Moreover, in HTR-8/SVneo cells, considered a good model of first-trimester EVT, SRIF also enhances migration. An involvement of the cyclic AMP pathway in mediating SRIF effects on proliferation and migration is suggested. Our data support the idea that SRIF regulates early trophoblast functions mainly through an interaction with SSTR2.

Original language	English
Pages (from-to)	660-670
Number of pages	11
Journal	Placenta
Volume	29
Issue number	8
DOIs	https://doi.org/10.1016/j.placenta.2008.05.009
Publication status	Published - Aug 2008

Keywords

Cell proliferation
Cyclic AMP
Migration
Phospholipase A2
Somatostatin
Trophoblast-derived cell lines

ASJC Scopus subject areas

Obstetrics and Gynaecology

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10.1016/j.placenta.2008.05.009

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title = "Somatostatin as a Regulator of First-Trimester Human Trophoblast Functions",

abstract = "We have tested the hypothesis that human early trophoblast is a target for somatostatin (SRIF) regulatory actions. We report for the first time that SSTR2A and 2B transcripts and proteins are present in first-trimester human chorionic villi and the trophoblast-derived HTR-8/SVneo and JAR cells. In both cell lines, SSTR are functional since SRIF inhibits cyclic AMP pathway, stimulates arachidonic acid release and enhances cell proliferation. Moreover, in HTR-8/SVneo cells, considered a good model of first-trimester EVT, SRIF also enhances migration. An involvement of the cyclic AMP pathway in mediating SRIF effects on proliferation and migration is suggested. Our data support the idea that SRIF regulates early trophoblast functions mainly through an interaction with SSTR2.",

keywords = "Cell proliferation, Cyclic AMP, Migration, Phospholipase A2, Somatostatin, Trophoblast-derived cell lines",

author = "C. Biondi and Ferretti, {M. E.} and L. Lunghi and S. Medici and F. Cervellati and L. Abelli and F. Bertoni and E. Adinolfi and F. Vesce and G. Bartolini and A. Papi and S. D'Andrea and S. Berton and G. Baldassarre",

year = "2008",

month = aug,

doi = "10.1016/j.placenta.2008.05.009",

language = "English",

volume = "29",

pages = "660--670",

journal = "Placenta",

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AU - Biondi, C.

AU - Ferretti, M. E.

AU - Lunghi, L.

AU - Medici, S.

AU - Cervellati, F.

AU - Abelli, L.

AU - Bertoni, F.

AU - Adinolfi, E.

AU - Vesce, F.

AU - Bartolini, G.

AU - Papi, A.

AU - D'Andrea, S.

AU - Berton, S.

AU - Baldassarre, G.

PY - 2008/8

Y1 - 2008/8

N2 - We have tested the hypothesis that human early trophoblast is a target for somatostatin (SRIF) regulatory actions. We report for the first time that SSTR2A and 2B transcripts and proteins are present in first-trimester human chorionic villi and the trophoblast-derived HTR-8/SVneo and JAR cells. In both cell lines, SSTR are functional since SRIF inhibits cyclic AMP pathway, stimulates arachidonic acid release and enhances cell proliferation. Moreover, in HTR-8/SVneo cells, considered a good model of first-trimester EVT, SRIF also enhances migration. An involvement of the cyclic AMP pathway in mediating SRIF effects on proliferation and migration is suggested. Our data support the idea that SRIF regulates early trophoblast functions mainly through an interaction with SSTR2.

AB - We have tested the hypothesis that human early trophoblast is a target for somatostatin (SRIF) regulatory actions. We report for the first time that SSTR2A and 2B transcripts and proteins are present in first-trimester human chorionic villi and the trophoblast-derived HTR-8/SVneo and JAR cells. In both cell lines, SSTR are functional since SRIF inhibits cyclic AMP pathway, stimulates arachidonic acid release and enhances cell proliferation. Moreover, in HTR-8/SVneo cells, considered a good model of first-trimester EVT, SRIF also enhances migration. An involvement of the cyclic AMP pathway in mediating SRIF effects on proliferation and migration is suggested. Our data support the idea that SRIF regulates early trophoblast functions mainly through an interaction with SSTR2.

KW - Cell proliferation

KW - Cyclic AMP

KW - Migration

KW - Phospholipase A2

KW - Somatostatin

KW - Trophoblast-derived cell lines

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AN - SCOPUS:49049109229

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EP - 670

JO - Placenta

JF - Placenta

IS - 8

ER -

Somatostatin as a Regulator of First-Trimester Human Trophoblast Functions

Abstract

Keywords

ASJC Scopus subject areas

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