In the present study, we have evaluated the apoptotic effect of soluble human MHC class I (sHLA-I) antigens on CD8+ T lymphocytes. sHLA-I antigens and β2-microglobulin-free HLA class I heavy chains, isolated from serum, induced apoptosis on phytohemagglutinin-activated CD8+ T lymphocytes in autologous and allogeneic combinations. The extent of CD8+ T cell apoptosis depends on the degree of activation, time of incubation with sHLA-I antigens and amount of sHLA-I antigens added to the cultures. Apoptosis is induced by the interaction of Fas (CD95)+ cells with soluble Fas ligand which is released following binding of sHLA-I antigens to CD8 molecules. These results suggest that sHLA-I antigens may regulate immune responses by inducing apoptosis in activated CD8+ T cells.
|Number of pages||9|
|Publication status||Published - 2000|
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