SNAP-25 in neuropsychiatric disorders

Irene Corradini; Claudia Verderio; Mariaelvina Sala; Michael C. Wilson; Michela Matteoli

doi:10.1111/j.1749-6632.2008.03995.x

SNAP-25 in neuropsychiatric disorders

Irene Corradini, Claudia Verderio, Mariaelvina Sala, Michael C. Wilson, Michela Matteoli

Istituto Clinico Humanitas

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic studies of human populations and of some mouse models implicate alterations in SNAP-25 gene structure, expression, and/or function in contributing directly to these distinct neuropsychiatric and neurological disorders.

Original language	English
Title of host publication	Annals of the New York Academy of Sciences
Pages	93-99
Number of pages	7
Volume	1152
DOIs	https://doi.org/10.1111/j.1749-6632.2008.03995.x
Publication status	Published - Jan 2009

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1152
ISSN (Print)	00778923
ISSN (Electronic)	17496632

Keywords

ADHD
Calcium channels
Epilepsy
Schizophrenia
SNAP-25

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1111/j.1749-6632.2008.03995.x

Cite this

@inproceedings{8e3d289d854c4eb3935bca670cc1d770,

title = "SNAP-25 in neuropsychiatric disorders",

abstract = "SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic studies of human populations and of some mouse models implicate alterations in SNAP-25 gene structure, expression, and/or function in contributing directly to these distinct neuropsychiatric and neurological disorders.",

keywords = "ADHD, Calcium channels, Epilepsy, Schizophrenia, SNAP-25",

author = "Irene Corradini and Claudia Verderio and Mariaelvina Sala and Wilson, {Michael C.} and Michela Matteoli",

year = "2009",

month = jan,

doi = "10.1111/j.1749-6632.2008.03995.x",

language = "English",

isbn = "9781573317351",

volume = "1152",

series = "Annals of the New York Academy of Sciences",

pages = "93--99",

booktitle = "Annals of the New York Academy of Sciences",

}

TY - GEN

T1 - SNAP-25 in neuropsychiatric disorders

AU - Corradini, Irene

AU - Verderio, Claudia

AU - Sala, Mariaelvina

AU - Wilson, Michael C.

AU - Matteoli, Michela

PY - 2009/1

Y1 - 2009/1

N2 - SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic studies of human populations and of some mouse models implicate alterations in SNAP-25 gene structure, expression, and/or function in contributing directly to these distinct neuropsychiatric and neurological disorders.

AB - SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic studies of human populations and of some mouse models implicate alterations in SNAP-25 gene structure, expression, and/or function in contributing directly to these distinct neuropsychiatric and neurological disorders.

KW - ADHD

KW - Calcium channels

KW - Epilepsy

KW - Schizophrenia

KW - SNAP-25

UR - http://www.scopus.com/inward/record.url?scp=58549092591&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58549092591&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2008.03995.x

DO - 10.1111/j.1749-6632.2008.03995.x

M3 - Conference contribution

C2 - 19161380

AN - SCOPUS:58549092591

SN - 9781573317351

VL - 1152

T3 - Annals of the New York Academy of Sciences

SP - 93

EP - 99

BT - Annals of the New York Academy of Sciences

ER -

SNAP-25 in neuropsychiatric disorders

Abstract

Publication series

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this