SNAP-25 in neuropsychiatric disorders

Irene Corradini, Claudia Verderio, Mariaelvina Sala, Michael C. Wilson, Michela Matteoli

Research output: Chapter in Book/Report/Conference proceedingConference contribution


SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic studies of human populations and of some mouse models implicate alterations in SNAP-25 gene structure, expression, and/or function in contributing directly to these distinct neuropsychiatric and neurological disorders.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Number of pages7
Publication statusPublished - Jan 2009

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)00778923
ISSN (Electronic)17496632


  • ADHD
  • Calcium channels
  • Epilepsy
  • Schizophrenia
  • SNAP-25

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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