Smoking as an independent determinant of Barrett’s esophagus and, to a lesser degree, of reflux esophagitis

Rosa Filiberti; Vincenzo Fontana; Antonella De Ceglie; Sabrina Blanchi; Enzo Grossi; Domenico Della Casa; Teresa Lacchin; Marina De Matthaeis; Orazio Ignomirelli; Roberta Cappiello; Monica Foti; Francesco Laterza; Vito Annese; Gaetano Iaquinto; Massimo Conio

doi:10.1007/s10552-014-0518-8

Smoking as an independent determinant of Barrett’s esophagus and, to a lesser degree, of reflux esophagitis

Rosa Filiberti, Vincenzo Fontana, Antonella De Ceglie, Sabrina Blanchi, Enzo Grossi, Domenico Della Casa, Teresa Lacchin, Marina De Matthaeis, Orazio Ignomirelli, Roberta Cappiello, Monica Foti, Francesco Laterza, Vito Annese, Gaetano Iaquinto, Massimo Conio

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To evaluate the role of smoking in Barrett’s esophagus (BE) and erosive esophagitis (E) compared to endoscopic controls with no BE or E. Smoking is considered a cause of both BE and E, but results on this topic are quite controversial. Methods: Patients with BE (339), E (462) and controls (619: 280 with GERD (gastroesophageal reflux disease)-negative and 339 with GERD-positive anamnesis) were recruited in 12 Italian endoscopy units. Data were obtained from structured questionnaires. Results: Among former smokers, a remarkable upward linear trend was found in BE for all smoking-related predictors. In particular, having smoked for more than 32 years increased the risk more than two times (OR 2.44, 95 % CL 1.33–4.45). When the analysis was performed in the subgroup of subjects with GERD-negative anamnesis, the risk of late quitters (

Original language	English
Pages (from-to)	419-429
Number of pages	11
Journal	Cancer Causes and Control
Volume	26
Issue number	3
DOIs	https://doi.org/10.1007/s10552-014-0518-8
Publication status	Published - 2015

Keywords

Barrett’s esophagus
Esophagitis
Gastroesophageal reflux
Smoking

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/s10552-014-0518-8

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Filiberti, R., Fontana, V., De Ceglie, A., Blanchi, S., Grossi, E., Della Casa, D., Lacchin, T., De Matthaeis, M., Ignomirelli, O., Cappiello, R., Foti, M., Laterza, F., Annese, V., Iaquinto, G., & Conio, M. (2015). Smoking as an independent determinant of Barrett’s esophagus and, to a lesser degree, of reflux esophagitis. Cancer Causes and Control, 26(3), 419-429. https://doi.org/10.1007/s10552-014-0518-8

Filiberti, R , Fontana, V, De Ceglie, A, Blanchi, S, Grossi, E, Della Casa, D, Lacchin, T, De Matthaeis, M, Ignomirelli, O, Cappiello, R, Foti, M, Laterza, F, Annese, V, Iaquinto, G & Conio, M 2015, 'Smoking as an independent determinant of Barrett’s esophagus and, to a lesser degree, of reflux esophagitis', Cancer Causes and Control, vol. 26, no. 3, pp. 419-429. https://doi.org/10.1007/s10552-014-0518-8

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abstract = "Purpose: To evaluate the role of smoking in Barrett{\textquoteright}s esophagus (BE) and erosive esophagitis (E) compared to endoscopic controls with no BE or E. Smoking is considered a cause of both BE and E, but results on this topic are quite controversial. Methods: Patients with BE (339), E (462) and controls (619: 280 with GERD (gastroesophageal reflux disease)-negative and 339 with GERD-positive anamnesis) were recruited in 12 Italian endoscopy units. Data were obtained from structured questionnaires. Results: Among former smokers, a remarkable upward linear trend was found in BE for all smoking-related predictors. In particular, having smoked for more than 32 years increased the risk more than two times (OR 2.44, 95 % CL 1.33–4.45). When the analysis was performed in the subgroup of subjects with GERD-negative anamnesis, the risk of late quitters (",

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author = "Rosa Filiberti and Vincenzo Fontana and {De Ceglie}, Antonella and Sabrina Blanchi and Enzo Grossi and {Della Casa}, Domenico and Teresa Lacchin and {De Matthaeis}, Marina and Orazio Ignomirelli and Roberta Cappiello and Monica Foti and Francesco Laterza and Vito Annese and Gaetano Iaquinto and Massimo Conio",

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AU - Filiberti, Rosa

AU - Fontana, Vincenzo

AU - De Ceglie, Antonella

AU - Blanchi, Sabrina

AU - Grossi, Enzo

AU - Della Casa, Domenico

AU - Lacchin, Teresa

AU - De Matthaeis, Marina

AU - Ignomirelli, Orazio

AU - Cappiello, Roberta

AU - Foti, Monica

AU - Laterza, Francesco

AU - Annese, Vito

AU - Iaquinto, Gaetano

AU - Conio, Massimo

PY - 2015

Y1 - 2015

N2 - Purpose: To evaluate the role of smoking in Barrett’s esophagus (BE) and erosive esophagitis (E) compared to endoscopic controls with no BE or E. Smoking is considered a cause of both BE and E, but results on this topic are quite controversial. Methods: Patients with BE (339), E (462) and controls (619: 280 with GERD (gastroesophageal reflux disease)-negative and 339 with GERD-positive anamnesis) were recruited in 12 Italian endoscopy units. Data were obtained from structured questionnaires. Results: Among former smokers, a remarkable upward linear trend was found in BE for all smoking-related predictors. In particular, having smoked for more than 32 years increased the risk more than two times (OR 2.44, 95 % CL 1.33–4.45). When the analysis was performed in the subgroup of subjects with GERD-negative anamnesis, the risk of late quitters (

AB - Purpose: To evaluate the role of smoking in Barrett’s esophagus (BE) and erosive esophagitis (E) compared to endoscopic controls with no BE or E. Smoking is considered a cause of both BE and E, but results on this topic are quite controversial. Methods: Patients with BE (339), E (462) and controls (619: 280 with GERD (gastroesophageal reflux disease)-negative and 339 with GERD-positive anamnesis) were recruited in 12 Italian endoscopy units. Data were obtained from structured questionnaires. Results: Among former smokers, a remarkable upward linear trend was found in BE for all smoking-related predictors. In particular, having smoked for more than 32 years increased the risk more than two times (OR 2.44, 95 % CL 1.33–4.45). When the analysis was performed in the subgroup of subjects with GERD-negative anamnesis, the risk of late quitters (

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Smoking as an independent determinant of Barrett’s esophagus and, to a lesser degree, of reflux esophagitis

Abstract

Keywords

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