Small bowel carcinoma in hereditary nonpolyposis colorectal cancer

Piero Benatti, Luca Roncucci, Antonio Percesepe, Alessandra Viel, Monica Pedroni, Maria Grazia Tamassia, Fabiana Vaccina, Rossella Fante, Stefano De Pietri, Maurizio Ponz De Leon

Research output: Contribution to journalArticlepeer-review


A 53-yr-old man, a member of a hereditary nonpolyposis colorectal cancer (HNPCC) family, with previous colonoscopic polypectomies, presented for persisting vomiting and marked signs of dehydration. Previous radiological and endoscopic examinations of the upper digestive tract were negative, with the exception of the presence of a duodenal adenomatous polyp. Enteroclysis led to a diagnosis of obstruction at the Treitz angle due to a moderately differentiated adenocarcinoma. Microsatellite instability was demonstrated in the DNA extracted from the tumor. The patient was the carrier of a mutation in the intron 13 of the hMLH1 gene, one of the four mismatch repair genes known to be responsible for HNPCC.

Original languageEnglish
Pages (from-to)2219-2222
Number of pages4
JournalAmerican Journal of Gastroenterology
Issue number11
Publication statusPublished - Nov 1998

ASJC Scopus subject areas

  • Gastroenterology


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