SLIT's Prevention of the Allergic March

Federica Porcaro, Giovanni Corsello, Giovanni Battista Pajno

Research output: Contribution to journalReview articlepeer-review


PURPOSE OF REVIEW: The progression of atopic disorders from atopic dermatitis in infants to allergic rhinitis and asthma in children, adolescents, and adults defines the allergy march. Allergen immunotherapy is the only causal treatment altering the immunological mechanism underlying the allergic diseases. The sublingual administration route is more acceptable than the subcutaneous one in pediatric age.

RECENT FINDINGS: Several studies show the efficacy and safety profile of sublingual immunotherapy (SLIT) for the treatment of respiratory allergy diseases, but few data are available on its effect of primary and secondary prevention of allergic disease. The purpose of this manuscript is to review the latest studies addressing the effect of SLIT on the development of new sensitizations in not sensitized or already sensitized patients and progression of the allergy march.

Original languageEnglish
Pages (from-to)31
JournalCurrent Allergy and Asthma Reports
Issue number5
Publication statusPublished - Apr 21 2018
Externally publishedYes


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