Sleep, sleep deprivation, autonomic nervous system and cardiovascular diseases

Eleonora Tobaldini, Giorgio Costantino, Monica Solbiati, Chiara Cogliati, Tomas Kara, Lino Nobili, Nicola Montano

Research output: Contribution to journalArticlepeer-review


Sleep deprivation (SD) has become a relevant health problem in modern societies. We can be sleep deprived due to lifestyle habits or due to sleep disorders, such as insomnia, obstructive sleep apnea (OSA) and neurological disorders.One of the common element of sleep disorders is the condition of chronic SD, which has complex biological consequences. SD is capable of inducing different biological effects, such as neural autonomic control changes, increased oxidative stress, altered inflammatory and coagulatory responses and accelerated atherosclerosis.All these mechanisms links SD and cardiovascular and metabolic disorders. Epidemiological studies have shown that short sleep duration is associated with increased incidence of cardiovascular diseases, such as coronary artery disease, hypertension, arrhythmias, diabetes and obesity, after adjustment for socioeconomic and demographic risk factors and comorbidities.Thus, an early assessment of a condition of SD and its treatment is clinically relevant to prevent the harmful consequences of a very common condition in adult population.

Original languageEnglish
Pages (from-to)321-329
JournalNeuroscience and Biobehavioral Reviews
Publication statusPublished - 2017


  • Apnea
  • Autonomic nervous system
  • Cardiovascular diseases
  • Sleep deprivation

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


Dive into the research topics of 'Sleep, sleep deprivation, autonomic nervous system and cardiovascular diseases'. Together they form a unique fingerprint.

Cite this