Sirolimus-eluting versus uncoated stents in acute myocardial infarction

Christian Spaulding, Patrick Henry, Emmanuel Teiger, Kevin Beatt, Ezio Bramucci, Didier Carrié, Michel S. Slama, Bela Merkely, Andrejs Erglis, Massimo Margheri, Olivier Varenne, Ana Cebrian, Hans Peter Stoll, David B. Snead, Christoph Bode

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Sirolimus-eluting stents reduce rates of restenosis and reintervention, as compared with uncoated stents. Data are limited regarding the safety and efficacy of such stents in primary percutaneous coronary intervention (PCI) for acute myocardial infarction with ST-segment elevation. METHODS: We performed a single-blind, multicenter, prospectively randomized trial to compare sirolimus-eluting stents with uncoated stents in primary PCI for acute myocardial infarction with ST-segment elevation. The trial included 712 patients at 48 medical centers. The primary end point was target-vessel failure at 1 year after the procedure, defined as target-vessel-related death, recurrent myocardial infarction, or target-vessel revascularization. A follow-up angiographic substudy was performed at 8 months among 174 patients from selected centers. RESULTS: The rate of the primary end point was significantly lower in the sirolimus-stent group than in the uncoated-stent group (7.3% vs. 14.3%, P = 0.004). This reduction was driven by a decrease in the rate of target-vessel revascularization (5.6% and 13.4%, respectively; P

Original languageEnglish
Pages (from-to)1093-1104
Number of pages12
JournalNew England Journal of Medicine
Issue number11
Publication statusPublished - Sept 14 2006

ASJC Scopus subject areas

  • Medicine(all)


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