Single brain metastases from melanoma: Remarks on a series of 84 patients

Maurizio Salvati, Alessandro Frati, Alessandro D'Elia, Lorenzo Pescatori, Manolo Piccirilli, Andrea Pietrantonio, Maurizio Fazi, Antonio Santoro

Research output: Contribution to journalArticlepeer-review


The authors report on 84 patients with single melanoma brain metastasis surgically treated from 1997 to 2007. There were 46 males and 38 females; mean age was 41 years (range 24-58 years). All patients were surgically treated, and 52 of them received postoperative adjuvant therapy consisting of whole-brain radiation therapy (36), radiosurgery (9), or a combination of these two techniques (7). Brain recurrences were observed in 44 cases, of which 9 were local. Of the latter, seven were re-operated while the remaining two were treated by radiosurgery. At 1-year follow-up, the survival rate was 52% (32 patients) whereas only 12 patients (14%) were still alive after 2 years. None of the patients in which removal was subtotal survived for more than 6 months after surgical treatment. Three years after the onset of the brain metastasis, five patients (6%) were still alive. Survival was significantly influenced by treatment with regard to overall survival reported in other series. A review of literature, together with our own series, suggests that radical surgical treatment of the lesion possibly employing the internal no-touch technique has significantly increased survival in our patients (p0.05).

Original languageEnglish
Pages (from-to)211-217
Number of pages7
JournalNeurosurgical Review
Issue number2
Publication statusPublished - Apr 2012


  • Chemotherapy
  • Melanoma
  • Metastasis
  • Neurosurgery
  • Radiotherapy
  • Surgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery


Dive into the research topics of 'Single brain metastases from melanoma: Remarks on a series of 84 patients'. Together they form a unique fingerprint.

Cite this