Shc signaling in differentiating neural progenitor cells

Luciano Conti; Simonetta Sipione; Lorenzo Magrassi; Luca Bonfanti; Dorotea Rigamonti; Valentina Pettirossi; Marc Peschanski; Bassam Haddad; PierGiuseppe Pelicci; Gabriele Milanesi; Giuliana Pelicci; Elena Cattaneo

doi:10.1038/88395

Shc signaling in differentiating neural progenitor cells

Luciano Conti, Simonetta Sipione, Lorenzo Magrassi, Luca Bonfanti, Dorotea Rigamonti, Valentina Pettirossi, Marc Peschanski, Bassam Haddad, PierGiuseppe Pelicci, Gabriele Milanesi, Giuliana Pelicci, Elena Cattaneo

Research output: Contribution to journal › Article › peer-review

Abstract

Previously we found that the availability of ShcA adapter is maximal in neural stem cells but that it is absent in mature neurons. Here we report that ShcC, unlike ShcA, is not present in neural stem/progenitor cells, but is expressed after cessation of their division and becomes selectively enriched in mature neurons. Analyses of its activity in differentiating neural stem/progenitor cells revealed that ShcC positively affects their viability and neuronal maturation via recruitment of the PI3K-Akt-Bad pathway and persistent activation of the MAPK pathway. We suggest that the switch from ShcA to ShcC modifies the responsiveness of neural stem/progenitor cells to extracellular stimuli, generating proliferation (with ShcA) or survival/differentiation (with ShcC).

Original language	English
Pages (from-to)	579-586
Number of pages	8
Journal	Nature Neuroscience
Volume	4
Issue number	6
DOIs	https://doi.org/10.1038/88395
Publication status	Published - 2001

ASJC Scopus subject areas

Neuroscience(all)

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10.1038/88395

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title = "Shc signaling in differentiating neural progenitor cells",

abstract = "Previously we found that the availability of ShcA adapter is maximal in neural stem cells but that it is absent in mature neurons. Here we report that ShcC, unlike ShcA, is not present in neural stem/progenitor cells, but is expressed after cessation of their division and becomes selectively enriched in mature neurons. Analyses of its activity in differentiating neural stem/progenitor cells revealed that ShcC positively affects their viability and neuronal maturation via recruitment of the PI3K-Akt-Bad pathway and persistent activation of the MAPK pathway. We suggest that the switch from ShcA to ShcC modifies the responsiveness of neural stem/progenitor cells to extracellular stimuli, generating proliferation (with ShcA) or survival/differentiation (with ShcC).",

author = "Luciano Conti and Simonetta Sipione and Lorenzo Magrassi and Luca Bonfanti and Dorotea Rigamonti and Valentina Pettirossi and Marc Peschanski and Bassam Haddad and PierGiuseppe Pelicci and Gabriele Milanesi and Giuliana Pelicci and Elena Cattaneo",

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T1 - Shc signaling in differentiating neural progenitor cells

AU - Conti, Luciano

AU - Sipione, Simonetta

AU - Magrassi, Lorenzo

AU - Bonfanti, Luca

AU - Rigamonti, Dorotea

AU - Pettirossi, Valentina

AU - Peschanski, Marc

AU - Haddad, Bassam

AU - Pelicci, PierGiuseppe

AU - Milanesi, Gabriele

AU - Pelicci, Giuliana

AU - Cattaneo, Elena

PY - 2001

Y1 - 2001

N2 - Previously we found that the availability of ShcA adapter is maximal in neural stem cells but that it is absent in mature neurons. Here we report that ShcC, unlike ShcA, is not present in neural stem/progenitor cells, but is expressed after cessation of their division and becomes selectively enriched in mature neurons. Analyses of its activity in differentiating neural stem/progenitor cells revealed that ShcC positively affects their viability and neuronal maturation via recruitment of the PI3K-Akt-Bad pathway and persistent activation of the MAPK pathway. We suggest that the switch from ShcA to ShcC modifies the responsiveness of neural stem/progenitor cells to extracellular stimuli, generating proliferation (with ShcA) or survival/differentiation (with ShcC).

AB - Previously we found that the availability of ShcA adapter is maximal in neural stem cells but that it is absent in mature neurons. Here we report that ShcC, unlike ShcA, is not present in neural stem/progenitor cells, but is expressed after cessation of their division and becomes selectively enriched in mature neurons. Analyses of its activity in differentiating neural stem/progenitor cells revealed that ShcC positively affects their viability and neuronal maturation via recruitment of the PI3K-Akt-Bad pathway and persistent activation of the MAPK pathway. We suggest that the switch from ShcA to ShcC modifies the responsiveness of neural stem/progenitor cells to extracellular stimuli, generating proliferation (with ShcA) or survival/differentiation (with ShcC).

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Shc signaling in differentiating neural progenitor cells

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