TY - JOUR
T1 - Sex hormone receptors in benign and malignant salivary gland tumors
T2 - Prognostic and predictive role
AU - Aquino, Gabriella
AU - Collina, Francesca
AU - Sabatino, Rocco
AU - Cerrone, Margherita
AU - Longo, Francesco
AU - Ionna, Franco
AU - Losito, Nunzia Simona
AU - De Cecio, Rossella
AU - Cantile, Monica
AU - Pannone, Giuseppe
AU - Botti, Gerardo
PY - 2018/2/1
Y1 - 2018/2/1
N2 - The role of sex hormone receptors in human cancer development and progression has been well documented in numerous studies, as has the success of sex hormone antagonists in the biological therapy of many human tumors. In salivary gland tumors (SGTs), little and conflicting information about the role of the estrogen receptor alpha (ERα), progesterone receptor (PgR) and androgen receptor (AR) has been described and in most cases the use of sex hormone antagonists is not contemplated in clinical practice. In this study, we analyzed a panel of sex hormone receptors that have not been widely investigated in SGTs—ERα, PgR, AR, but also ERβ and GPR30—to define their expression pattern and their prognostic and predictive value in a case series of 69 benign and malignant SGTs. We showed the aberrant expression of AR in mucoepidermoid and oncocytic carcinoma, a strong relation between cytoplasmic ERβ expression and tumor grade, and a strong correlation between nuclear GPR30 expression and disease-free survival (DFS) of SGT patients.
AB - The role of sex hormone receptors in human cancer development and progression has been well documented in numerous studies, as has the success of sex hormone antagonists in the biological therapy of many human tumors. In salivary gland tumors (SGTs), little and conflicting information about the role of the estrogen receptor alpha (ERα), progesterone receptor (PgR) and androgen receptor (AR) has been described and in most cases the use of sex hormone antagonists is not contemplated in clinical practice. In this study, we analyzed a panel of sex hormone receptors that have not been widely investigated in SGTs—ERα, PgR, AR, but also ERβ and GPR30—to define their expression pattern and their prognostic and predictive value in a case series of 69 benign and malignant SGTs. We showed the aberrant expression of AR in mucoepidermoid and oncocytic carcinoma, a strong relation between cytoplasmic ERβ expression and tumor grade, and a strong correlation between nuclear GPR30 expression and disease-free survival (DFS) of SGT patients.
KW - Salivary gland tumors
KW - Sex hormone receptors
KW - Therapeutic targets
UR - http://www.scopus.com/inward/record.url?scp=85041295306&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041295306&partnerID=8YFLogxK
U2 - 10.3390/ijms19020399
DO - 10.3390/ijms19020399
M3 - Article
AN - SCOPUS:85041295306
SN - 1661-6596
VL - 19
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 2
M1 - 399
ER -