Severe constipation in Parkinson's disease relieved by botulinum toxin

Alberto Albanese; Giorgio Maria; AnnaRita Bentivoglio; Giuseppe Brisinda; Emanuele Cassetta; Pietro Tonali

doi:10.1002/mds.870120524

Severe constipation in Parkinson's disease relieved by botulinum toxin

Alberto Albanese, Giorgio Maria, AnnaRita Bentivoglio, Giuseppe Brisinda, Emanuele Cassetta, Pietro Tonali

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

A parkinsonian patient with severe outlet-type constipation was treated with injection of botulinum toxin into the puborectalis muscle. A total of 30 units (Botox) was injected in two sites. Resting anal pressure, maximum voluntary contraction, and pressure on straining were evaluated before treatment and 4, 8, 12, and 16 weeks afterward. Pressure values declined following treatment, the decline of pressure on straining ending by week 12. Proctography performed 8 weeks after treatment showed improvement in the anorectal angle and evacuation of barium paste. The clinical benefit lasted for ~12 weeks. The present data show that botulinum toxin is a promising tool for treating outlet-type constipation in Parkinson's disease.

Original language	English
Pages (from-to)	764-766
Number of pages	3
Journal	Movement Disorders
Volume	12
Issue number	5
DOIs	https://doi.org/10.1002/mds.870120524
Publication status	Published - 1997

Keywords

Botulinum toxin
Gastrointestinal dysfunction
Outlet-type constipation
Parkinson's disease
Puborectalis muscle

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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10.1002/mds.870120524

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abstract = "A parkinsonian patient with severe outlet-type constipation was treated with injection of botulinum toxin into the puborectalis muscle. A total of 30 units (Botox) was injected in two sites. Resting anal pressure, maximum voluntary contraction, and pressure on straining were evaluated before treatment and 4, 8, 12, and 16 weeks afterward. Pressure values declined following treatment, the decline of pressure on straining ending by week 12. Proctography performed 8 weeks after treatment showed improvement in the anorectal angle and evacuation of barium paste. The clinical benefit lasted for ~12 weeks. The present data show that botulinum toxin is a promising tool for treating outlet-type constipation in Parkinson's disease.",

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AU - Albanese, Alberto

AU - Maria, Giorgio

AU - Bentivoglio, AnnaRita

AU - Brisinda, Giuseppe

AU - Cassetta, Emanuele

AU - Tonali, Pietro

PY - 1997

Y1 - 1997

N2 - A parkinsonian patient with severe outlet-type constipation was treated with injection of botulinum toxin into the puborectalis muscle. A total of 30 units (Botox) was injected in two sites. Resting anal pressure, maximum voluntary contraction, and pressure on straining were evaluated before treatment and 4, 8, 12, and 16 weeks afterward. Pressure values declined following treatment, the decline of pressure on straining ending by week 12. Proctography performed 8 weeks after treatment showed improvement in the anorectal angle and evacuation of barium paste. The clinical benefit lasted for ~12 weeks. The present data show that botulinum toxin is a promising tool for treating outlet-type constipation in Parkinson's disease.

AB - A parkinsonian patient with severe outlet-type constipation was treated with injection of botulinum toxin into the puborectalis muscle. A total of 30 units (Botox) was injected in two sites. Resting anal pressure, maximum voluntary contraction, and pressure on straining were evaluated before treatment and 4, 8, 12, and 16 weeks afterward. Pressure values declined following treatment, the decline of pressure on straining ending by week 12. Proctography performed 8 weeks after treatment showed improvement in the anorectal angle and evacuation of barium paste. The clinical benefit lasted for ~12 weeks. The present data show that botulinum toxin is a promising tool for treating outlet-type constipation in Parkinson's disease.

KW - Botulinum toxin

KW - Gastrointestinal dysfunction

KW - Outlet-type constipation

KW - Parkinson's disease

KW - Puborectalis muscle

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Severe constipation in Parkinson's disease relieved by botulinum toxin

Abstract

Keywords

ASJC Scopus subject areas

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