Severe constipation in Parkinson's disease relieved by botulinum toxin

Alberto Albanese, Giorgio Maria, AnnaRita Bentivoglio, Giuseppe Brisinda, Emanuele Cassetta, Pietro Tonali

Research output: Contribution to journalArticlepeer-review


A parkinsonian patient with severe outlet-type constipation was treated with injection of botulinum toxin into the puborectalis muscle. A total of 30 units (Botox) was injected in two sites. Resting anal pressure, maximum voluntary contraction, and pressure on straining were evaluated before treatment and 4, 8, 12, and 16 weeks afterward. Pressure values declined following treatment, the decline of pressure on straining ending by week 12. Proctography performed 8 weeks after treatment showed improvement in the anorectal angle and evacuation of barium paste. The clinical benefit lasted for ~12 weeks. The present data show that botulinum toxin is a promising tool for treating outlet-type constipation in Parkinson's disease.

Original languageEnglish
Pages (from-to)764-766
Number of pages3
JournalMovement Disorders
Issue number5
Publication statusPublished - 1997


  • Botulinum toxin
  • Gastrointestinal dysfunction
  • Outlet-type constipation
  • Parkinson's disease
  • Puborectalis muscle

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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