Serum-Soluble HLA-G Is Associated with Specific IgE in Patients with Allergic Rhinitis and Asthma

G. Ciprandi, A. Corsico, P. Pisati

Research output: Contribution to journalArticlepeer-review


Allergic rhinitis (AR) and allergic asthma (AA) are characterized by T helper (Th)2-polarized immune response. Soluble human leukocyte antigen G (sHLA-G) molecule plays an immunomodulatory activity. Previously, it has been reported that children with AR or AA had higher sHLA-G levels in comparison with normal subjects. Thus, the present study aimed at confirming these data in adults and investigating whether there was a relationship between serum sHLA-G levels and serum IgE levels, in patients with AR or AA. One hundred twenty symptomatic patients, suffering from respiratory symptoms, were enrolled: 45 non-allergic and 75 allergic. A group of 44 healthy subjects was considered as control. Serum sHLA-G levels and serum allergen-specific IgE were determined by immunoenzymatic methods. Allergic patients had significantly higher levels of sHLA-G molecules than non-allergic patients and normal controls (p <0.0001). There was no difference between AR and AA. sHLA-G moderately related with allergen-specific IgE both in AR (r = 0.468) and AA patients (r = 0.479). The present study confirms that serum sHLA-G molecules are significantly increased in allergic disease and demonstrates that sHLA-G levels are related with allergen-specific IgE levels.

Original languageEnglish
Pages (from-to)1630-1634
Number of pages5
Issue number5
Publication statusPublished - Sept 24 2014


  • allergic rhinitis
  • asthma
  • serum sHLA-G
  • serum-specific IgE

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)


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